Prostate cancer affects a large number of humans with significant costs. Despite treatments, including Androgen Deprivation Therapy (chemical castration), several patients see their cancer progress to potentially metastatic resistant forms. These forms will significantly reduce the lifespan of patients. The current models (standard cancer cell line culture or animal models) do not effectively reflect the tumour microenvironment, so we have developed a tissue-engineered 3D human prostate cancer model based on our bladder cancer model. We want to investigate the role of the extracellular matrix's stiffness in the tumour's vicinity in the invasion process, which will ultimately lead to metastases, particularly in connection with the role of cancer-associated fibroblasts. Human 3D prostate will be reconstructed using the self-assembly method, and their mechanical parameters will be evaluated and modulated by adding cancer-associated fibroblasts and/or chemicals to the tissue. The invasion of such tissues by prostate cancer cells will be monitored by confocal microscopy and correlated to the stiffness. From a perspective, a better knowledge of the regulation of mechanical properties of stroma by cancer cells through cancer-associated fibroblasts should help to develop new treatments. Also, such a model could be used for personalized medicine as a drug screening platform.
Research area, student roles & skills
Research area: Our research mainly focuses on the reconstruction of genitourinary organs using tissue engineering (urethra and vagina, with the support of the Canadian Institutes for Health Research). Our perspective is the clinical applications of our findings. Nevertheless, our models are so close to native tissue; we have established tight collaborations with experts to develop more basic research projects and to investigate complex pathologies such as microbiologic issues (E.coli urinary tract infection (in partnership with Diana Food/Symrise) and HIV vaginal infection (with Merck support)) or cancers (bladder and prostate, with the support of Ferring innovation and Canadian Urological Association, supports).
Student roles: The project will make it possible to become familiar with classic cell culture techniques and more elaborate techniques such as tissue engineering, particularly the innovative self-assembly technique developed at LOEX to reconstruct many tissues. It will also allow an analytical approach via molecular biology, flow cytometry, mechanical resistance analysis and various 3D imaging techniques. During this project, the student will learn how to activate normal prostate fibroblasts into Cancer-Associated Fibroblasts and quantify this activation by flow cytometry techniques. He will also learn how to reconstruct a normal or pathologic prostate mucosa by tissue engineering. He will modulate the stiffness or the stroma using normal fibroblasts and/or cancer-associated fibroblasts to reconstruct the stromal compartment of the mucosa. Cancer-associated fibroblasts should increase the stiffness of the stroma, which can be reduced by chemical modulation. These points will be measured using mechanical testing. Finally, the invasive ability of prostate cancer cells will be monitored on these tissue after cancer cell spheroid implantation in the epithelial compartment. This project will be conducted in collaboration with an experienced project manager and a master's student responsible for the project. First, the basics of the project are established. Then, the project will be organized so that all the points are seen, and certain parts can be carried out in parallel.
Skills required: The student should have basics in cell culture and be interested in biology, bioengineering and tissue engineering. The student should also be rigorous, meticulous, curious, persevering, and want to learn. A wide variety of tissue reconstruction projects related to clinical and fundamental projects are carried out in our team and other LOEX groups, and this is an excellent opportunity for a student to learn about many subjects.
2. A bottom-up approach to characterizing the mechanical properties of skin tissue in vitro
Human skin is the body’s largest organ and provides a physical barrier to the external environment. As part of this function, skin tissue sustains the mechanical forces developed during movement and exercise without failure or rupture. Epidermolysis Bullosa (EB) is a spectrum of debilitating genetic conditions that are characterized by mechanical fragility of skin tissue and present with symptoms such as skin blistering, erosion, and ulceration, under seemingly trivial mechanical load. EB research needs to focus on both improving the quality of life for patients through better acute symptom control with patient-specific skin grafts, along with the development of new cellular therapeutics that can treat the long-term condition. Importantly, the mechanical properties of skin tissue, the effect of EB mutations on tissue strength, and how grafts distribute mechanical load are critical considerations that are often overlooked. The focus of this project will be on investigating how mutations to cytoskeletal and adhesion proteins lead to EB type-specific changes to epidermal mechanical properties. This project combines cutting edge techniques from tissue culture, molecular biology, and mechanical engineering to characterize the mechanical properties of skin tissue models grown in vitro, to better understand the molecular mechanisms of EB. From a therapeutic perspective, the student will work on the development of engineered cell lines that can improve intercellular adhesion strength and integration of skin grafts using synthetic cell adhesion molecules and receptors.
Research area, student roles & skills
Research area: The overarching goal of the CTELab (https://carleton.ca/ctelab/) is to investigate how cells and tissues become fragile in disease, and to reverse engineer the mechanical properties of cells and tissues for use in regenerative medicine. Within this general theme, we aim to 1) understand how a spectrum of debilitating genetic diseases causes skin tissue weakening, fracture, and failure, 2) investigate the mechanisms of neural cell injury under the high strain rate loading conditions associated with traumatic brain injury, 3) characterize how cellular level forces drive changes in cell shape.
Student roles: The student will take an active role in designing and performing experiments. This includes maintaining cell lines, developing constructs for fluorescently tagging proteins in cells, optical microscopy measurements, and mechanical measurements on cells and tissues. The student will work independently on their project, but as part of the Cell and Tissue Engineering lab with the support of both the faculty mentor and graduate students in the lab. The student will be required to complete necessary health and safety training in order to work on an independent project. The student will meet frequently with the mentor to discuss experiments and data that the student has analyzed.
Skills required: The student should have a keen interest in interdisciplinary research that includes techniques from cell biology, and tools to characterize their properties from the physical sciences and engineering. Preference will be given to a student with experience in cell culture, and or optical microscopy, but this is not a requirement. Due to the interdisciplinary nature of the project students from biology, biomedical engineering, engineering, or physics could be suitable candidates. The student should have a keen interest in hands on work and performing experiments which will form a major part of the project.
3. Acute and chronic effects of obesity on cardiovascular disease risk factors
Supervisor: Sylvia Santosa
University: Concordia University (Montréal campus)
Location: Montreal, Québec
Start date: 2027-07-26 (flexible)
Disciplines: Biology, Biological Sciences, Medical Sciences, Medicine, Molecular Biology, Nutrition, Health Studies, Immunology, Nursing, Physiology, Sports Science
Overweight people who have been so since childhood are at especially high risk of heart disease and stroke. I want to know why these people are at higher risk. Maybe it is because being overweight as a child affects the body differently than becoming overweight as an adult? Specific questions I would like to answer are: How does developing obesity as a child affect fat and muscle differently than if we gain weight as adults? Do obese adults who were overweight children respond differently to weight loss than those who became obese as adults?
Research area, student roles & skills
Research area: Our lab specializes in the study of nutrition, obesity and metabolism. We aim to answer the question of why some people with obesity develop diseases and others do not. To answer these questions, we examine the problem from a physiological and biological perspective. Our projects involve recruiting participants, collecting samples (blood, adipose tissue, muscle) from them for analysis in the lab. Interns have the opportunity to be involved in some or all aspects of the study.
Student roles: The student will assist in recruitment of participants, study visits, and lab work associated with the experiments.
Skills required: -Lab experience -Able to perform literature searches -Enthusiastic -Quick learner -Resourceful -Comfortable working with people, previous experience with statistical analysis, an asset
4. Aging-associated changes in alternative mRNA splicing
Supervisor: Adonis Skandalis
University: Brock University (St. Catherines campus)
Location: St Catharines, Ontario
Start date: 2027-06-01 (flexible)
Disciplines: Biology, Biological Sciences, Veterinary Science and Medicine
To capture, and potentially ameliorate, the multifaceted types and consequences of DNA damage to the aging phenotype it is clearly necessary to study aging at the organismal level. Our analysis of DNA damage and its consequences for aging has utilized Xylocopa virginica, which is an organism with haploid males and diploid females. This offers several critical advantages mutational and aging studies: 1.Full organismal complexity and interactions allowing to analyze multiple tissues and organs. 2. Exposure to known environmental mutagens such as UV radiation, oxidative and thermal stress but also pesticides. 3. Short aging chronological interval. 4. Haploid genomes which overcome the complexity of genetic analysis of heterozygosity. Bioinformatic analysis of young and aging males has revealed multiple signatures of DNA damage including characteristic expression of stress response genes, alternative mRNA splicing, and epigenetic genome modifiers that are known to control cellular response to damage by regulating autophagy, cell senescence, and apoptosis. In the proposed project, we will focus on the changes in alternative splicing observed during aging in the brain. Using RNASeq and qPCR the student will characterize and quantify aging related alternative splicing in young and old haploids and diploids and contrast their alternative splicing patterns.
Research area, student roles & skills
Research area: Aging is a complex biological phenomenon associated with the functional decline of a variety of processes from the biochemical and molecular level to tissue, organ, and organismal level. The principal mechanistic process thought to contribute to aging is DNA damage leading to a cascading effect of genetic and epigenetic changes, impaired signaling cascades, and altered cellular fates like apoptosis and senescence that ultimately lead to the aging phenotype.
Student roles: The student will be guided and will be ultimately expected to analyze transcriptomic data in order to characterize alternative splicing patterns. Due to the time constraints, the raw data will be obtained prior to the student's arrival. The student will then be guided to choose appropriate gene targets for further analysis using quantitative PCR. This will involve isolating and preparing RNA and cDNA, primer design, reaction optimization, and data analysis. As we expect the analysis to lead to a publication the student will be given the opportunity but not obliged to contribute to the writing of the manuscript.
Skills required: The student will be trained in the use of computers and bioinformatic tools and therefore should be comfortable with computers. The student will be trained in advanced molecular biology protocols but previous experience in elementary skills such as molarity and dilution calculations, the use of micro-pipettors, balances, pH meters, gel electrophoresis, employing sterile technique etc will greatly speed up the training.
5. BRM-related gene expression patterns in human tumors
Supervisor: Sevtap Savas
University: Memorial University of Newfoundland (St. John's campus)
Location: St. John'S, Newfoundland and Labrador
Start date: 2027-05-25 (flexible)
Disciplines: Biology, Biological Sciences, Computer Science, Genetics, Health Studies, Medical Sciences, Molecular Biology
The protein product of the BRM gene is a subunit of an important protein complex called SWI/SNF. This complex is involved in remodeling our DNA molecule and influencing gene expression. There are many published studies linking abnormalities of this gene to cancer, including risk of developing cancer (for example, lung cancer) and patient outcomes (for example, death from cancer). We previously examined this gene in colorectal and thyroid cancers, and lung adenocarcinomas. In this study, we aim to examine the gene expression levels of this gene in human tumors – preferably in The Cancer Genome Atlas (TCGA) datasets.
We hypothesize that the expression levels of BRM differ between tumors of different patients. We also hypothesize that this difference is associated with different expression levels of other genes and biological pathways. By analyzing the differentially expressed genes/biological pathways and the disease and patient characteristics, we hope to find out how BRM expression levels are linked to this disease biologically.
Cancer is a common disease. Understanding the relation of BRM to human cancers may create exciting opportunities for future studies. Since the BRM gene is linked to multiple human cancers, we expect that this study may also significantly contribute to our understanding of many cancers at the biological level. We can focus on cancers with the largest sample sizes in the TCGA dataset, such as stomach and esophageal cancers, but other cancer sites are also great candidates.
Research area, student roles & skills
Research area: My lab works on cancer. Among the specific research interests are cancer genetics, genetic variations as prognostic biomarkers, survival studies, patient reported outcomes, relation of BRM gene to tumor features, genomics applications, and patient experiences and their predictors. The majority of our work includes statistical and computational analyses.
Student roles: The student has an important role in the success of this exciting study. The student will learn and apply a suite of computational and statistical methods during this study. Using these methods, the student will examine the BRM expression levels in tumors and categorize the patients into groups; retrieve, format, analyze the gene expression data; and conduct statistical comparisons (e.g. between different patient groups). All project work will be recorded in a lab notebook to allow reproduction of the work. A project report will also be drafted by the student at the end of the study. While general directions and support on statistical analyses will be provided by the PI, the student is expected to learn and work independently as much as possible. This work may complement other research done in the lab. Therefore, it is possible that the student’s work may contribute to a manuscript and they can be a co-author in this manuscript. All of these activities and new skills, knowledge and research expertise to be gained can benefit the future research roles of the student.
Skills required: The study will include the gene expression data provided by public resources, such as the TCGA project. The data analysis will require computational investigations, such as identification of differentially expressed genes, pathway analyses, and application of statistical methods. A strong computational background in retrieval, management, formatting, and analysis of large-scale biological data is required. Writing codes may also be required. Since many gene expression analysis tools have established R packages that can used in this project, a knowledge of R-environment may be necessary. Training for statistical analysis will be provided.
6. Branching Process Models for Polyploidy Detection: Building a Generalizable Genomic Pipeline Across Genomes
Supervisor: Yue Zhang
University: Thompson Rivers University (Kamloops campus)
Whole-genome duplication is one of the most consequential forces in eukaryotic evolution, yet accurately detecting and timing these events remains computationally challenging. This project extends my published branching process framework (Journal of Computational Biology, accepted 2025; RECOMB-CG 2025) into a generalizable, open-source pipeline that integrates complementary divergence measure signals. The intern will apply this pipeline to at least two new genomic datasets, benchmark it against existing WGD tools, and co-author a methods manuscript targeting a peer-reviewed bioinformatics journal. The work directly extends an ongoing graduate project in the lab and will result in a publicly released R/Python tool.
Research area, student roles & skills
Research area: My research sits at the intersection of mathematical biology, comparative genomics, and statistical modelling. I develop branching process models to characterize the distribution of sequence similarity between homologous gene pairs, with the goal of detecting and dating ancient whole-genome duplication (WGD) events across eukaryotic lineages. This work has been applied to fish (Salmonidae, Teleosts), and multiple plant families (Malvaceae, Solanaceae, Buxus, Tetracentron), and is supported by an NSERC Discovery Grant (2024–2029) and a Genome BC grant (2025–2028).
Student roles: The student will conduct literature review on whole-genome duplication and comparative genomics methods, perform computational analyses using the branching process pipeline on new genomic datasets, assist with benchmarking and validation of results, contribute to open-source tool documentation, and co-author a research report and manuscript for journal submission.
Skills required: Undergraduate degree (or final year) in bioinformatics, computational biology, mathematics, statistics, or computer science Proficiency in Python and/or R; comfort working in a Linux/command-line environment Foundational knowledge of molecular biology or genomics (understanding of gene families, sequence alignment, or evolutionary biology is an asset) Experience with version control (Git/GitHub) Strong quantitative and analytical skills; familiarity with probability or statistical modelling is an advantage but not required
7. Caractérisation biologique et géologique du Fjord du Saguenay
Notre équipe est en train de procéder à la cartographie des habitats du Fjord du Saguenay. Trois éléments principaux sont cartographiés. Premièrement, de l'imagerie satellitaire, aérienne et par drone est utilisée pour faire une cartographie linéaire des côtes du Fjord, ce qui implique une identification du type de côte, sa caractérisation, et son positionnement. Des analyses multi-temporelles et multi-échelles sont aussi effectuées. Deuxièmement, les habitats côtiers sont cartographiés. Encore une fois, de l'imagerie est combinée à des méthodes de classification orientée-objets pour identifier, caractériser et délimiter les habitats intertidaux et littoraux. Dans certains cas, nous évaluons aussi des méthodes pour cartographier les habitats côtiers subtidaux. Troisièmement, nous utilisons des technologies sous-marines, comme les échosondeurs multifaisceaux et les véhicules sous-marins téléguidés, pour cartographier le fond marin ainsi que les parois verticales submergées du Fjord. Des échantillons biologiques et de sédiments sont parfois collectés, et quand ce n'est le cas, de l'imagerie sous-marine permet leur identification.
Research area, student roles & skills
Research area: Géomaticien de formation, mes expertises spécifiques en géomatique appliquée sont les sciences spatiales (incluant la télédétection acoustique et optique, les drones, et l'analyse spatiale), la cartographie des habitats, et la géomorphométrie (la modélisation et quantification tridimensionnelle du terrain et du paysage). J'applique ces disciplines aux milieux marins, dans des contextes tels que la conservation et la gestion des ressources.
Student roles: Les personnes étudiantes assisteront à la collecte de données sur le terrain, à leur traitement dans des logiciels spécialisés, à leur analyse et leur interprétation. Ils pourront aussi collaborer à l'écriture de rapports et d'articles scientifiques.
Skills required: Les compétences des personnes étudiantes guideront les tâches à effectuer au sein du projet. Certaines compétences recherchées incluent, mais ne sont pas limitées à: des compétences en géomatique (cartographie, systèmes d'information géographique, télédétection, analyse spatiale), en écologie du paysage, en écologie spatiale, en biologie (identification des espèces), en géomorphologie, ou en océanographie.
8. Computational Approaches to the Genetics of Heart Disease
Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide. While numerous genetic variants associated with cardiometabolic risk factors have been identified through genome-wide association studies (GWAS), much remains unknown about how these genetic factors actually cause disease or interact with environmental and lifestyle exposures to influence disease risk.
This project will investigate gene–environment interactions underlying major cardiovascular risk factors, including adiposity, blood pressure, and smoking behavior. Using multiple large-scale genetic datasets from established cohort studies that we already have, the research will identify genetic variants and polygenic risk scores associated with plasma traits (proteins and metabolites) and evaluate how their effects are modified by environmental exposures such as diet quality, physical activity, smoking, and psychosocial factors.
A particular focus will be placed on determining whether genetic effects vary across different levels of environmental exposure and whether these interactions differ according to age. Advanced statistical models, including AI, will be developed to integrate genetic and non-genetic risk factors, enabling a more comprehensive understanding of the mechanisms driving cardiovascular disease susceptibility.
The student will participate in all aspects of data preparation, quality control, statistical analyses, and interpretation of results. The findings will contribute to improved understanding of the biological pathways linking genetic predisposition and environmental exposures to cardiovascular health. Ultimately, the project aims to generate evidence that supports more personalized prevention strategies and identifies potential intervention targets for reducing the burden of cardiovascular disease.
Research area, student roles & skills
Research area: My research program focuses on the genetic and environmental determinants of cardiovascular disease (CVD), with a particular emphasis on cardiovascular genomics, genetic epidemiology, and gene–environment interactions. By integrating large-scale genome-wide association study (GWAS) data with clinical, lifestyle, and environmental risk factors, as well as other -omic data, our work seeks to identify biological pathways that contribute to cardiometabolic disease. We employ advanced statistical and computational approaches to investigate how genetic susceptibility combines with and interacts with modifiable exposures such as diet, physical activity, smoking, and psychosocial factors to influence cardiovascular health across the life course.
Student roles: The student will serve as an active member of our multidisciplinary cardiovascular genetics research team. Under the supervision of the project investigator and with support from collaborators including statisticians and data specialists, the student will contribute to all major phases of the project. Responsibilities will include conducting literature reviews, preparing and managing research datasets, performing data cleaning and quality-control procedures, and assisting with the development and implementation of statistical analyses. The student will help generate genetic risk scores, evaluate gene–environment interactions, and assess associations between genetic variants, environmental exposures, and cardiovascular risk factors using established analytical methods. The student will participate in weekly supervisory and team meetings, present progress updates, and contribute to discussions regarding study design, interpretation of findings, and troubleshooting analytical challenges. Additional responsibilities may include creating data visualizations, summarizing results, conducting sensitivity analyses, and helping document analytical workflows to ensure reproducibility. As the project progresses, the student will assist in synthesizing findings into reports, conference presentations, and manuscript drafts suitable for peer-reviewed publication. Through these activities, the student will gain practical experience in genetic epidemiology, biostatistics, scientific communication, and collaborative research. The role is designed to provide comprehensive training in modern cardiovascular research while enabling the student to make meaningful contributions to a project focused on understanding how genetic and environmental factors jointly influence cardiovascular disease risk and prevention. The student will have the opportunity to present at weekly meetings and at one local scientific meeting.
Skills required: The ideal student will have a background in one or more of the following disciplines: genetics, epidemiology, biostatistics, bioinformatics, data science, or medical sciences. Experience with statistical analysis software (e.g., R, Stata, SAS, or Python) is highly desirable. Familiarity with genetic epidemiology, genome-wide association studies (GWAS), or large health datasets would be advantageous but is not required. Strong analytical, quantitative, and communication skills, attention to detail, and an interest in cardiovascular research are essential. The student should be comfortable working independently while collaborating effectively within a multidisciplinary research team.
9. Conservation genetics of Blanding's turtle
Supervisor: Yann Surget-Groba
University: Université du Québec en Outaouais (Gatineau campus)
The Blanding's turtle is a endangered species in Canada. The main threats to the species are habitat loss, road mortality and increased egg predation by subsidized predators (predators favored by human activity). In Outaouais, the population of Blanding's turtles which is mainly present in Pontiac has been monitored since the end of the 2000s. During a recent sampling campaign, we identified 185 different individuals in the area, with an estimated population size of 326 individuals. However, the age structure of the population is heavily skewed towards older individuals, with only 13 juveniles identified, most over 10 years old. This lack of juveniles in the population can be explained in two ways: 1) our sampling method is not effective in capturing young, or 2) a recruitment problem exists in this population. Several arguments seem to favor the second, notably the presence of juveniles in other populations sampled with similar methods, the high rate of predation observed on turtle nests, and an effective size estimated by genetic markers showing the low number of non-breeding individuals. If this second hypothesis were confirmed, the future of the population would be strongly compromised, with individuals disappearing from the population (natural mortality or mortality linked to human activities) no longer being replaced. The main objective of this project is to better evaluate recruitment in the Outaouais Blanding’s turtle population. We will aim to answer several questions:
1) How does the age structure of the population change over time?
2) What is the nesting success rate?
3) What type of habitat is used by juveniles?
4) What is the risk of genetic erosion in this population?
Research area, student roles & skills
Research area: The Ecological and Environmental Genomics lab lead by prof. Yann Surget-Groba is par of the Institute of Temperate Forest Sciences located in the small village of Ripon in the Outaouais region of Quebec, Canada. We use genomic tools to study the evolutionary and conservation biology of various organisms, in particular to study the effect of different forest management systems on biodiversity, and to develop efficient biodiversity inventory methods based on the analysis of environmental DNA. We also investigate the landscape genomics of forest trees to understand their ability to adapt to a rapidly changing environment.
Student roles: This project is part of a larger project involving several students and many participants from several institutions (provincial and federal governments, Nature Conservancy Canada ...) and the student will be required to work in close collaboration with the other members of the team. The student will first be involved in fieldwork, for a mark-recapture study aimed at monitoring a Blanding turtle population, then radiotracking of released juveniles and adult females, and finally monitoring turtle nests for predation. Then, work in the lab will involve DNA extractions, PCR and/or qPCR. Other side projects are available in the group upon interest (bioinformatics, database development, electronics/transmitter development, environmental DNA analyses...).
Skills required: The student will be required to be confortable conducting fieldwork (if no previous experience doing fieldwork, experience in outdoor activities such as hiking, camping, etc is required). Good physical condition is required to conduct fieldwork in difficult condition (access to the research sites can be difficult requiring hiking on uneven ground carrying equipment and canoes). Previous experience in a molecular laboratory (with knowledge of basic methods such as DNA extraction, PCR and gel electrophoresis) is preferable. Previous field experience with freshwater turtles handling and/or radiotracking would be useful.
10. Cross modal brain plasticity underlying mechanical and thermal hypersensitivity in rodent models of sensory deprivation.
Supervisor: Mathieu Piché
University: Université du Québec à Trois–Rivières
Location: Trois-Rivières, Québec
Start date: 2027-05-03 (flexible)
Disciplines: Biology, Engineering, Engg-Biomedical, Engg-Electrical, Engg-Computer, Engg-Software, Neuroscience, Physiology, Psychology, Computer Science, Biological Sciences, Electronic Systems, Engg-Systems and Technology, Medical Sciences, Medicine, Statistics, Veterinary Science and Medicine
In this project, brain recordings in the cortex and amygdala will be used to examine how these regions contribute to pain hypersenstivity. Single-unit, multi-unit and local field potential analyses will be used to characterize the activity of neurons and neuronal populations.
Research area, student roles & skills
Research area: Neuroscience has made significant advances in understanding how the brain adapts to changes in sensory inputs. One example of this adaptability and brain plasticity is observed in rodent models of visual deprivation. In these models, anophthalmic animals or dark-reared animals show behavioral improvment in other sensory modalities. The last decades of research have shown the brain mechainsms of these behavioral compensations. Such plastic changes demonstrate the brain’s capacity to rewire itself in response to altered sensory experiences. Howover, the mechanisms that lead to pain hypersensitivity following visual deprivation have been overlooked.
Student roles: The trainee will be responsible for data analyses of brain recordings already available. Several methods will be taught and the trainee will be free to analyze various data sets with a variety of analysis techniques.
Skills required: No specific skill is required, but the trainee should demonstrate a strong interest in data analyses of brain recordings.
11. Cumulative effects modeling of landuse, climate change, and management intervention impacts on Atlantic Salmon to inform recovery planning
Atlantic Salmon streams are subject to a variety of cumulative habitat impacts from development and environmental change in their watersheds, ranging from sediment inputs to riparian habitat loss, eutrophication leading to hypoxia, and elevated temperatures and reduced flows under climate change. Given the complexities of these cumulative impacts, the long-term outcomes of different management interventions are not always clear because different sites are subject to different and multiple limiting factors. Subsequently, prioritizing which threat(s) to address is difficult and often non-intuitive. Therefore, there is an urgent need for a credible planning tool for facilitating this process.
The objectives of this project are to apply a credible and easily used cumulative effects modelling platform to prioritize recovery actions for Atlantic Salmon in Québec
Research area, student roles & skills
Research area: Dr. Enders is primarily interested in fish ecology, fish and habitat conservation and restoration, and environmental impact assessments of anthropogenic flow and climate changes on fish populations. The Riverine Fish Ecology Lab of the INRS – Centre Eau Terre Environnement has broad research interests in conservation biology, ecophysiology, fish behaviour and bioenergetics, and aquatic ecology to provide scientific advice for Species at Risk and Fish Habitat Protection. Freshwater fishes are used as research models for experiments conducted in both the laboratory and the field.
Student roles: In this field study, the role of the student will involve to actively participate in divers research tasks. The student's responsibilities begin with a thorough understanding of the study objectives, research questions, and relevant background information. This familiarity will enable the student to grasp the context and purpose of the field work, align their efforts accordingly, and contribute effectively to the overall research goals.
Prior to embarking on the work, the student will play an important role in preparing the necessary data. This involves organizing and gathering existing data, but potentially also to assemble the tools, instruments, and materials required for data collection and field experiments. By assisting in this preparation process, the student ensures that all the necessary resources are available and in proper working condition, facilitating a smooth and efficient study.
The student will actively engage in the modelling exercise. This includes following established protocols and methodologies, implementing planned procedures, and conducting observations or measurements as required. The student will conduct the modelisation. The student's active involvement allows for the modelisation of reliable and accurate data, forming the foundation for the research findings and conclusions.
In summary, the student's role in this modelling exercise encompasses familiarizing themselves with study objectives and background information, assisting in the preparation of experimental setup, actively participating in data collection and lab experiments, taking accurate notes, and ensuring the quality and integrity of the collected data. By fulfilling these responsibilities, the student contributes to the success of the research endeavor.
Skills required: To participate in this modeling study effectively, we encourage students with an educational background in the field of biology or environmental sciences or equivalent degree (e.g., ecology, wildlife biology, natural resource management, or other relevant discipline) to apply. We are looking for a creative and self-motivated student who has critical thinking and problem-solving skills. The student should be able to work effectively both independently and collaboratively in a team. Adaptability is another important skill for this study.
12. Data-Driven Assessment of Oil Spill Response Technologies for Sustainable Environmental Management
Supervisor: Chunjiang An
University: Concordia University (Montréal campus)
Oil spills can cause significant environmental, ecological, and socio-economic impacts, and the selection of appropriate response technologies depends on oil type, spill location, environmental conditions, response time, operational feasibility, and potential environmental trade-offs. This 12-week project will develop a data-driven assessment of oil spill response technologies to support sustainable environmental management and evidence-based decision-making.
The intern will review recent scientific literature, technical reports, and publicly available response guidelines related to oil spill response and remediation technologies. These may include mechanical recovery, sorbents and natural materials, dispersants, shoreline cleanup, bioremediation, in-situ burning, oily waste treatment, and other emerging sustainable response options. The intern will help build a structured database summarizing technology type, application conditions, treatment or recovery performance, advantages, limitations, environmental concerns, waste generation, and sustainability considerations.
Depending on the student’s background and interests, the project may involve data cleaning, visualization, statistical analysis, classification, or simple multi-criteria decision-support methods to compare different response options under various environmental and operational scenarios. The project will not require fieldwork or advanced laboratory experiments, but it will provide interdisciplinary training in environmental engineering, oil spill response, data analysis, and sustainability assessment.
The expected outputs include a literature-based database, summary tables, visual figures, and a short technical report identifying key trends, knowledge gaps, and promising sustainable response strategies. The results may support future research publications, proposal development, and decision-support tools for oil spill preparedness, response planning, and sustainable remediation.
Research area, student roles & skills
Research area: My research focuses on environmental pollution control, emergency response, and sustainable remediation, with particular emphasis on oil spill response, shoreline protection, contaminant fate and transport, waste management, and environmental risk assessment. The research integrates environmental engineering, data analysis, modelling, sustainability assessment, and decision-support tools to support evidence-based decision-making for spill preparedness, response, and remediation. Current work also explores data-driven methods for evaluating environmental technologies, identifying performance trade-offs, and improving response strategies under different operational, ecological, and climate-related conditions, with the goal of advancing resilient and sustainable environmental management.
Student roles: The intern will play an active role in developing a data-driven assessment of oil spill response technologies. The student will first conduct a focused literature review on oil spill response and remediation methods, including mechanical recovery, sorbents, dispersants, shoreline cleanup, bioremediation, in-situ burning, oily waste treatment, and emerging sustainable technologies. The intern will identify relevant peer-reviewed papers, technical reports, and publicly available response guidelines, and extract key information related to technology type, application conditions, treatment or recovery performance, environmental considerations, operational constraints, waste generation, and sustainability implications.
The student will then help design and populate a structured database to organize the extracted information in a consistent and transparent format. Depending on their background, the intern may conduct data cleaning, classification, visualization, summary statistics, or simple comparative analysis using Excel, Python, R, or other suitable tools. The student may also support the development of figures, technology comparison tables, and a preliminary decision-support matrix to compare response options under different environmental and operational scenarios.
The intern will participate in regular meetings with the supervisor and research team to discuss progress, refine the database structure, interpret findings, and identify knowledge gaps. The student is expected to work both independently and collaboratively, maintain clear documentation of data sources and assumptions, and communicate results effectively. By the end of the internship, the intern will prepare a short technical report, presentation slides, and visual materials summarizing key findings, limitations, and potential future research directions. These outputs may support future publications, proposals, and decision-support tools for sustainable oil spill response and environmental management.
Skills required: The student should have a background in environmental engineering, civil engineering, environmental science, chemistry, data science, or a related field. Basic knowledge of environmental pollution, water quality, remediation, oil spill response, or sustainability assessment is desirable. Experience with literature review, data organization, Excel, Python, R, statistics, visualization, or simple modelling would be an asset, but advanced programming experience is not required. The student should be motivated, detail-oriented, and able to work independently and collaboratively. Strong communication skills, critical thinking, and interest in interdisciplinary environmental research are important for this project.
13. Development of dPCR assays for environmental DNA detection
Supervisor: Yann Surget-Groba
University: Université du Québec en Outaouais (Gatineau campus)
Conservation of threatened species first requires a good understanding of the distribution and abundance of the different populations. For many species, traditional monitoring methods (direct observation, trapping, ...) require a considerable investment. To facilitate detection and monitoring of endangered species, it is important to develop new approaches that are more sensitive and rapid. For the last few years, DNA left by animals in their environment (environmental DNA or eDNA) proved useful to detect aquatic species. However the traditional eDNA analysis method relies on quantitative PCR (qPCR) that is limited by its sensitivity to PCR inhibitors and the need to use standard curves to estimate DNA concentration. Digital PCR (dPCR) is a new promising approach for eDNA analysis but its use is still limited. The objective of this project will be to compare qPCR and dPCR efficiency to detect various invasive or endangered aquatic species.
Research area, student roles & skills
Research area: The Ecological and Environmental Genomics lab lead by prof. Yann Surget-Groba is par of the Institute of Temperate Forest Sciences located in the small village of Ripon in the Outaouais region of Quebec, Canada. We use genomic tools to study the evolutionary and conservation biology of forest organisms, in particular to study the effect of different forest management systems on biodiversity, and to develop efficient biodiversity inventory methods based on the analysis of environmental DNA. We also investigate the landscape genomics of forest trees to understand their ability to adapt to a rapidly changing environment.
Student roles: The student primary role will be to adapt existing qPCR assays to a dPCR approach, and then compare the efficiency and sensitivity of both methods to detect target species' DNA. Fieldwork for eDNA collection is possible but not mandatory. Participation to other projects conducted in the lab is possible upon interest (bioinformatics, database development, electronics/transmitter development, radiotracking...).
Skills required: The student will be required to have some basic knowledge in evolutionary biology and molecular biology. Previous experience in a molecular laboratory (with knowledge of basic methods such as DNA extraction, PCR and gel electrophoresis) is preferable.
14. Early Postpartum Depression Risk Detection Through Federated Analysis of Smartwatch Behavioral and Physiological Patterns
MAMAI (Maternal Assistance and Monitoring through Artificial Intelligence) is a framework for the early detection of postpartum depression using continuous data from consumer smartwatches. The project applies on-device federated learning to identify behavioral and physiological patterns associated with declining maternal well-being, allowing the model to learn from sensitive health data without that data ever leaving the participant's device. The architecture is built on interoperable health-data standards (OGC SensorThings API and HL7 FHIR) to ensure a secure, scalable data pipeline, and pairs this technical foundation with a culturally aware context model and a support component that draws on verified provincial health resources. The goal is to enable earlier, privacy-preserving identification of postpartum depression risk so that affected mothers can be connected to appropriate care sooner.
Research area, student roles & skills
Research area: My research focuses on AI-driven health monitoring through wearable and sensor data, with an emphasis on privacy-preserving machine learning. My current work centers on MAMAI (Maternal Assistance and Monitoring through Artificial Intelligence), a framework for early detection of postpartum depression that applies on-device federated learning to behavioral and physiological patterns from smartwatches. I combine interoperable data-standard architectures (OGC SensorThings API and HL7 FHIR) with culturally aware context modeling and verified clinical resources, bridging the technical challenge of building secure, standards-compliant wearable data pipelines with the human-centered goal of supporting maternal mental health.
Student roles: The student will contribute to the development of MAMAI's early postpartum depression detection pipeline. On the health-science side, this involves reviewing clinical literature to identify behavioral and physiological markers of declining maternal well-being (e.g., sleep disruption, heart rate variability, activity and circadian patterns) and translating them into measurable features from smartwatch data. On the computer-science side, the student will help design and implement on-device federated learning models, working with wearable time-series data and contributing to a secure, standards-compliant pipeline (HL7 FHIR, OGC SensorThings API). Day to day, the student will engage in feature engineering, model development and evaluation, literature review, and documentation, collaborating closely with the research team and contributing to publications.
Skills required: We are seeking a student (or two with complementary strengths) bridging health sciences and computer science. From a biology/health background: familiarity with maternal and perinatal health, and the ability to identify clinically meaningful behavioral and physiological markers of postpartum depression (sleep, heart rate variability, activity, circadian rhythm). From computer science: strong Python skills, a machine learning foundation, and an interest in federated learning and on-device training. Experience with wearable sensor data, time-series analysis, and health-data standards (HL7 FHIR, OGC SensorThings) is an asset. The student should be self-directed and motivated to contribute to human-centered AI for maternal mental health.
15. Ecology of insect species associated with carcasses and cadavers/Écologie des espèces d’insectes associés aux carcasses et aux cadavres
The project aims to advance our understanding of the ecological processes driving decomposition and insect succession on vertebrate remains. In forensic contexts, insect communities are widely used to estimate the postmortem interval (PMI), yet the reliability of these estimates depends on a robust understanding of how environmental conditions influence colonization patterns and decomposition dynamics.
This research focuses on the temporal and spatial organization of arthropod communities associated with carrion, with particular emphasis on successional processes, species interactions, and environmental constraints. Through a combination of controlled field experiments and observational studies, carcasses are exposed under varying conditions (e.g., habitat type, degree of confinement, climate, and seasonality) to quantify rates of decomposition and patterns of insect colonization.
The project integrates ecological theory, including succession theory, niche differentiation, and metacommunity dynamics, to interpret how species assemble and interact throughout the decomposition process. In addition, it examines the functional roles of key taxa (e.g., Diptera and Coleoptera) in driving decomposition rates and shaping microhabitat conditions. Advanced analytical approaches, such as time-series modeling and spatial analysis, are used to identify deterministic versus stochastic components of community assembly.
By bridging fundamental ecology with applied forensic science, this work seeks to improve the accuracy and reliability of PMI estimation while contributing to broader ecological understanding of decomposer systems. The findings also have implications beyond forensics, including nutrient cycling, biodiversity conservation, and the ecological functioning of transient resource patches.
Research area, student roles & skills
Research area: My research focuses on insect ecology, with an emphasis on the spatiotemporal dynamics of arthropod communities in decomposing systems and managed ecosystems. I investigate insect succession on carrion to improve forensic applications, while also integrating ecological theory (e.g., metacommunity dynamics) and advanced tools such as LiDAR and machine learning to study biodiversity patterns in forest and agricultural landscapes. My work aims to bridge fundamental ecology with applied issues in conservation, forest management, and forensic science.
Student roles: The student will be involved in field sampling of carcasses, including collecting insect specimens and recording detailed observations on decomposition and environmental conditions. They will assist in the identification of common and easily recognizable insect taxa, with guidance provided for more advanced identification. The student will also contribute to setting up and maintaining experimental designs. Data recording and organization will be essential components of the role. If desired, the student will have the opportunity to contribute to presenting the results at a regional scientific conference.
Skills required: The project is suited for students in biology, ecology, entomology, or related fields, with a strong interest in insect ecology and decomposition. Prior experience with insect identification is an asset but not required, as training will be provided. Essential qualities include attention to detail, curiosity, and willingness to learn. The student should be comfortable conducting fieldwork under variable conditions and working both independently and in a team. Basic data analysis and organizational skills are desirable, as the project involves handling ecological data and following structured protocols.
16. Examination of red blood cell physiology during blood bank storage
Supervisor: Syed Qadri
University: Ontario Tech University (Oshawa campus)
Location: Oshawa, Ontario
Start date: 2027-06-01 (flexible)
Disciplines: Biology, Biological Sciences, Biochemistry, Chemistry, Engg-Biomedical, Engg-Biological, Health Studies, Medical Sciences, Medicine, Molecular Biology, Pathology, Pharmacology, Pharmacy, Physiology, Veterinary Science and Medicine
Storage of red blood cell (RBC) units under blood banking conditions is essential to ensure timely availability for clinical blood transfusion. Our research aims to identify the mechanisms that influence storage-induced susceptibility to pathophysiologic cell stress. Cellular alterations in RBCs will be examined using cytofluorometry techniques. This project aims to uncover key biochemical changes with RBCs that dictate RBC quality and posttransfusion outcomes.
Research area, student roles & skills
Research area: The overarching objective of our research is to understand the molecular mechanisms regulating red blood cell (RBC) product quality during blood bank storage; and RBC function in systemic diseases. More specifically, the research in our lab aims at defining the influence of exogenous and endogenous factors that impact RBC lifespan by using various cellular and molecular biology approaches as well as in vivo studies.
Student roles: Student responsibilities/tasks: - Involved in project design. Student will simultaneously perform thorough literature reviews on the research topic - Performing in vitro biochemical assays - Data analysis and interpretation
Skills required: Students should have completed at least one of the following courses (Minimum 70%): Human physiology, Biochemistry, Cellular & molecular biology. Familiarity with basic lab skills is preferred.
17. Examining the effects of manipulative warming, nutrient addition and vegetation composition on greenhouse gas emissions from boreal peatlands
Supervisor: Jianghua Wu
University: Memorial University of Newfoundland (St. John's campus)
Northern peatlands, persistently contributing to climate cooling, store ~30% of the world’s terrestrial soil carbon (C), equivalent to half of the total atmospheric C. This enormous storage of soil C results from a persistently greater production than its decomposition. Moreover, northern peatlands are globally significant sources of methane (CH4). Therefore, northern peatlands represent a globally important reservoir of soil C and play an important role in the global C cycle and climate system. The ecosystem greenhouse gas (GHG) emission function of northern peatlands is tightly coupled to climate through its feedback to changes in hydrology and vegetation composition. However, the majority of peatlands are located in boreal ecosystems where the climate is experiencing a warmer climate and increased atmospheric nitrogen (N) deposition also occurs. Therefore, the ecosystem functions of GHG emissions of boreal peatlands are susceptible to changes in climate via changes in soil climate and vegetation composition that may result from the projected warming and increased atmospheric N deposition. However, no field experiments have been carried out to examine how the GHG emission of boreal peatlands responds to the concurrent changes in soil climate, N addition, and vegetation composition. This unknown knowledge has caused significant uncertainty in projecting the role that boreal peatlands will play in the global C cycling in the context of climate change due to the lack of understanding of how ecosystem functions respond to climate change and human disturbances. To address the above outstanding issue, this proposed program is to examine how the GHG emissions in boreal peatlands respond to the concurrent warming and N addition and how they are regulated by changes in vegetation composition via a globally unique manipulative field experiment. This exploratory project will lead us to enhance our mechanistic understanding of how boreal peatlands respond to climate and land-use changes.
Research area, student roles & skills
Research area: My general research interests are environmental modeling, terrestrial biogeochemical cycling, ecosystem ecology, climatic and environmental change. My specific research interests, via field observation and measurements and ecosystem modeling, are to examine how the hydrological and carbon cycling and greenhouse gas emissions in boreal peatlands and forests changes with climate change and human disturbances, and how these changes in functions affect the ecosystem services provided by boreal peatlands and forest. My extended research interests include other types of wetlands, boreal forests and cultivated soils for mitigating greenhouse gas emissions, ecosystem restoration, and sustainable management of natural resources.
Student roles: The student will assist my Ph.D. students to conduct the following (but not limited to) field sampling and measurements, laboratory analysis, and data analysis: (1) Take the air samples from static chambers and soil water samples at our field sites. (2) Measure the soil temperature, soil moisture and water table depth at the locations where the soil water and air samples are taken. (3) Process the samples and measure the concentration of carbon dioxide, methane and nitrous oxide in the air samples on GHG Gas Chromatography (GC) in the lab. (4) Measure the carbon isotopic signature for carbon dioxide in the air samples on a carbon isotopic analyzer in the lab. (5) Process the water samples and measure total organic carbon (TOC) and total nitrogen (TN) for the water samples using a TOC/TN analyzer at the lab. (6) Analyze the water samples for spectral absorbance on the UV-Vis Spectrophotometer in the lab. (7) Calculate the GHG fluxes from the data and process other data using MS Excel.
The students will spend 2 days at the field for the field sampling and measurements and the rest of the week at the lab.
You will be involved in the cutting edge research projects on carbon cycling and biogeochemistry of boreal ecosystems, and be exposed to the up-to-date research techniques on biogeochemistry, carbon cycling, and greenhouse gas emissions in boreal ecosystems.
Skills required: Some knowledge of physical geography, soil science, ecosystem ecology and biology and wetlands, in general, will be an asset. No field work experience is required. However, the applicants must be comfortable working in the field for field sampling and measurement.
18. Exposing 3D organoids to mechanical strain in vitro
Sustaining and generating mechanical forces is a normal part of physiology for tissues. For example, endothelial cells in blood vessels are exposed to mechanical shear by blood flow, keratinocytes in skin sustain tensile forces during movement and exercise, and epithelial cells lining the gut are exposed to mechanical strain during peristalsis. The loss of cellular mechanical properties is associated with a number of diseases, which present with symptoms such as blistering and cracking of tissues. Despite this, our understanding of the link between cell mechanics and tissue function is limited.
During this project, the student will work with a custom-built device that has been developed in the CTELab to mechanically stretch simple adherent cell layers. The student will adapt this system so that it is capable of exposing 3D cultures to mechanical strain at controllable loading rates, which is a more physiologically relevant model of in vivo tissues. The student will gain experience in cell culture, device fabrication and sterilization, and optical microscopy as part of this work. A longer-term aim of this project is to analyze protein level changes in 3D cultured tissues (organoids) in response to changes in mechanical strain amplitude and strain rate as a model for both tissue physiological function and disease. One potential application includes exposing brain organoids to the mechanical loading conditions associated with Traumatic Brain Injury (TBI) and screening for drugs that confer a neuroprotective effect against TBI. The student will work towards this goal by expanding the platform into a mid-throughput format for drug testing.
Research area, student roles & skills
Research area: The overarching goal of the CTELab (https://carleton.ca/ctelab/) is to investigate how cells and tissues become fragile in disease, and to reverse engineer the mechanical properties of cells and tissues for use in regenerative medicine. Within this general theme, we aim to 1) understand how a spectrum of debilitating genetic diseases causes skin tissue weakening, fracture, and failure, 2) investigate the mechanisms of neural cell injury under the high strain rate loading conditions associated with traumatic brain injury, 3) characterize how cellular level forces drive changes in cell shape.
Student roles: The student will take an active role in designing and performing experiments. This includes maintaining cell lines, developing constructs for fluorescently tagging proteins in cells, optical microscopy measurements, and mechanical measurements on cells and tissues. The student will work independently on their project, but as part of the Cell and Tissue Engineering lab with the support of both the faculty mentor and graduate students in the lab. The student will be required to complete necessary health and safety training in order to work on an independent project. The student will meet frequently with the mentor to discuss experiments and data that the student has analyzed.
The student will work on the development of the cell stretching device expanding the format so that it can be used to stretch 3D cultures in mid throughput. This will include using techniques from soft lithography and additive manufacturing. The student will then work towards using the device for drug testing on brain organoids through our collaborators at the Ottawa Hospital Research Institute. This work will include cell and organoid culture.
Skills required: The student should have a keen interest in interdisciplinary research that includes techniques from cell biology, and tools to characterize their properties from the physical sciences and engineering. Preference will be given to a student with experience in cell culture, and or optical microscopy, but this is not a requirement. Due to the interdisciplinary nature of the project students from biology, biomedical engineering, engineering, or physics could be suitable candidates. The student should have a keen interest in hands on work and performing experiments which will form a major part of the project.
19. Field Collection, Isolation, and Molecular Identification of Wood-Decay Fungi in
Supervisor: Sarath Vega Gutierrez
University: University of British Columbia (Vancouver campus)
Wood-decay fungi are among the most ecologically and economically significant organisms in forest ecosystems, driving nutrient cycling, carbon dynamics, and wood degradation processes that directly affect timber value and forest health. Although wood decay fungi are widely studied, the group of wood pigmenting fungi is understudied and produces secondary metabolites with a diverse range of applications, such as UV blockers, solar cells, and dyes.
This project will engage the intern in an integrated research program that combines field collection, laboratory culture, and molecular identification of wood-decay fungi from the Malcom Knapp Research Forest in British Columbia. The intern will gain hands-on experience across the full pipeline of fungal research — from boots-on-the-ground fieldwork to bench-level laboratory techniques used in modern mycological research.
The intern will participate in field expeditions to collect decayed wood samples, isolate fungal cultures using standard mycological techniques, including surface sterilization, and extract genomic DNA from pure cultures. Molecular identification will be carried out by amplifying and sequencing phylogenetically informative markers — primarily the ITS region — followed by BLAST searches and phylogenetic analyses to assign taxonomic identities to isolates. All isolates will be cataloged in a georeferenced occurrence database contributing to a broader survey of wood-decay fungal diversity in Canadian forests.
Research area, student roles & skills
Research area: My research focuses on wood-inhabiting fungi — particularly wood-decay and wood-pigmenting species — and the secondary metabolites they produce. I use molecular identification, fungal culture, and secondary metabolite identification to develop bio-based solutions for wood protection and durable coatings. My field program spans temperate forests in British Columbia and tropical sites in Peru. Broader interests include the durability of lignocellulosic materials, engineered wood products, and sustainable material design. I hold a Ph.D. in Wood Science & Engineering from Oregon State University, have industry experience in the wood industry, and am an incoming Assistant Professor in UBC's Wood Science Department.
Student roles: The intern will be embedded in an active research group at the UBC Wood Protection Lab, working closely with the supervising faculty member and graduate students throughout the entire 12-week program.
The intern will be an active research contributor from day one. By the end of the internship, they will be able to lead field collection expeditions alongside the supervising faculty member and graduate students, making real-time decisions about sampling strategy and site documentation. In the laboratory, they will be trained in and then independently execute fungal isolation, culture maintenance, DNA extraction, PCR amplification, and sequence-based identification under close mentorship.
Beyond the technical work, the intern will be expected to engage critically with the scientific literature on wood-decay fungal diversity and contribute to data interpretation and synthesis. The expectation is that the intern will co-author a short peer-reviewed paper — likely a short communication in a mycology or wood science journal — documenting the fungal species isolated from the sampled sites.
This is an opportunity for a motivated student to gain genuine research experience, including scientific writing and the publication process. The intern will participate in lab meetings, present their progress to the research group, and receive direct mentorship from supervising faculty and graduate students to prepare a manuscript draft before the internship concludes.
Skills required: The ideal candidate has a background in biology, forestry, environmental science, microbiology, or wood science, and a genuine interest in fungal biology and wood decay. This internship offers a unique opportunity to develop skills at the interface of field ecology and molecular biology, within an active research program.
The candidate should be able to use Microsoft Office, be able to do searches for literature review, and be willing to do field and lab work.
20. Fire history during the last millennium in the south Boreal region of Central Canada
In this study, we seek to investigate the fire dynamics (frequency and ecology) during the last ca. 1,000 years in Central Ontario, a region situated at the transition between the temperate and north-boreal climates, and thus very sensitive to climate change. We use soil and sediment cores extracted from various locations in the south boreal region of Central Ontario to reconstruct the fire ecology and frequency utilizing fossil charcoal particles. Radiocarbon dating of core sediments will provide a timescale for this change. This research will advance our understanding of forest ecosystems response to both rapid (decadal to centennial scale) and slower (millennial scale) climate change in Central Ontario, which is critical to designing adaptation and mitigation strategies to future climate change.
Research area, student roles & skills
Research area: I am a historical ecologist with focus on human dimensions of climate change. I use ecological and geological techniques to reconstruct the impact of human actions on Boreal and Arctic ecosystems, in particular the wetland to upland continuum.
Student roles: The student will work in a team of Canadian undergraduate and graduate students led by Professor Pendea. The main tasks will be to help: - collect soil, water, and vegetation samples in the field. An ability and willingness to work in rough terrain conditions is an asset. - chemically process soil samples. An ability to work in a lab using various chemical reagents is an asset. - identify and quantify various bioindicators under the microscope. Training on all aspects will be provided and, thus, no prior knowledge of this type of work is required.
Skills required: The student would be a senior undergraduate student (who finalized 2nd year at the time of application) in a Environmental Science, Geography, Biology, Ecology, or Geology programs. Knowledge of GIS and Quantitative methods (R language) is preferred but not required. The ideal candidate would also have some basic laboratory skills (biology and chemistry) as well as an ability to work in the field collecting soil, water, and vegetation samples. However, detailed training on all aspects of the work will be provided.
21. Functional analysis of NCK adaptor proteins as building blocks for cellular signalling
The response of cells to extracellular stimuli is mediated by signalling pathways that act downstream of membrane bound receptors. These pathways are commonly organized through inducible protein-protein interactions and have been highly conserved throughout evolution. Signals from receptors are often relayed through adaptor proteins, which serve as hubs to recruit appropriate target proteins and guide signals to specific cellular pathways. The main goal is this research program is to decipher how normal cells use these adaptor proteins to coordinate specific responses from a given extracellular cue. In the case of tyrosine kinase receptors and phospho-tyrosine signalling, this is exemplified by adaptors composed exclusively of SH2 (Src Homology 2) and SH3 protein interaction domains, such as NCK1 and NCK2. NCK1/2 adaptors mediate the interaction between phosphorylated tyrosine (pTyr) containing proteins (via their single SH2) and effectors that contain poly-proline motifs (via one of their 3 SH3s). Little is known about NCK1 and NCK2 specificity as both adaptors are generally considered to be indistinguishable. We have shown using protein interaction analyses that NCK1 and NCK2 signalling networks contain both common and unique components. Recently, we have demonstrated that SH3 domain position within their host protein (in particular NCKs) is crucial for their interaction with targets. The proposed project aims at defining how NCK1/2 adaptors achieve specificity towards their targets. The identification and characterization of NCK1- and NCK2-specific targets will be instrumental to understanding how two adaptor proteins that appear identical nevertheless achieve specific functions in multiple aspects of cellular organization. Moreover, our studies will shed new light on SH2 and SH3 domains as protein interaction modules that mediate assembly of signalling complexes, and how they control the coordination of cellular responses.
Research area, student roles & skills
Research area: Our main goal is to decipher how normal cells establish a specific response to extracellular cues. To achieve this, our work seeks to determine how signalling networks are formed following cell stimulation with growth factors. We are particularly interested in signalling via modular protein interaction domains. We use state-of-the-art tools including proteomics, live-cell imaging and 3D biological models.
Student roles: The student will work on a small-scale project that is related to the thesis of a PhD candidate in the laboratory. The student is expected to learn how to perform molecular biology, biochemistry and cell biology experiments related to proteins in a cutting-edge life science research environment. The student is expected to be able to perform experiments independently by the end of the internship. The student will design and execute protocols, perform experiments, analyse data and report them (figures, tables, short reports) to the team. The lab is composed of 6-8 people from all over the world, at different stages of their career.
Skills required: The student must have a basic knowledge in biology/biochemistry, with at least some laboratory experience. The student is expected to be motivated, meticulous, and to have positive interactions with the team.
In this project, fungi will be tested for their ability to tolerate hydrocarbons and use them as a carbon source.
Research area, student roles & skills
Research area: My research area is in mycology and specifically in the ecology and diversity of fungi.
Student roles: The student will isolate fungal cultures from soil and test them under exposure to hydrocarbons. The student will also use existing cultures from a culture collection.
Fungal isolates will be evaluated for their ability to grow on media containing hydrocarbons.
Skills required: The ideal candidate would have a good background in biology, biodiversity and ecology. Laboratory skills and previous training in mycology and/or microbiology would be an asset.
23. Gene Regulatory Network Inference Algorithms from Single-Cell RNA Sequencing Data
Supervisor: Yue Zhang
University: Thompson Rivers University (Kamloops campus)
Inferring gene regulatory networks from scRNA-seq data is a central challenge in systems biology, with direct implications for understanding cell differentiation, disease mechanisms, and drug targets. Numerous GRN inference algorithms have been proposed, including GENIE3, SCENIC, PPCOR, and deep learning-based methods — but systematic, reproducible benchmarking across diverse cell types and dataset sizes remains limited. This project will evaluate and compare leading GRN inference algorithms on publicly available scRNA-seq datasets, assessing performance metrics such as accuracy, scalability, and robustness to noise and sparsity. The intern will work alongside an ongoing graduate project in the lab, contributing complementary analyses and co-authoring a benchmark report and manuscript targeting a bioinformatics or systems biology journal.
Research area, student roles & skills
Research area: My research applies statistical modelling and machine learning to large-scale biological datasets, with a focus on genomics and transcriptomics. My lab is currently investigating gene regulatory network (GRN) inference from single-cell RNA sequencing (scRNA-seq) data. This work connects to my broader expertise in high-dimensional biological data analysis, LASSO-based feature selection, and algorithm development for genomic applications.
Student roles: The student will conduct a literature review on GRN inference methods and benchmarking frameworks, perform computational analyses running and evaluating multiple algorithms on scRNA-seq datasets, and contribute to a final benchmark report and co-authored manuscript for journal submission.
Skills required: Undergraduate degree (or final year) in bioinformatics, computational biology, statistics, or computer science Proficiency in R and/or Python; familiarity with Bioconductor or scanpy is an asset Basic understanding of gene expression data and transcriptomics concepts Strong analytical and quantitative skills; interest in algorithm evaluation and reproducible research
The focus of this project is one of Canada’s largest and “sickest” lakes; Lake Winnipeg. Lake Winnipeg is an important part of local life: traditionally, recreationally, and commercially, however imbalanced algal populations can impede lake usage. Water samples are collected aboard the motor vessel NAMAO, which traverses Lake Winnipeg in Spring, Summer, and Autumn. This time-series features 65 sample sites and opportunist dense algal population sampling. Students will focus primarily on understanding the diversity and functional roles of giant viruses (Nucleocytoviricota) associated with dense algal populations called “blooms”. Blooms are sometimes harmful as they can produce toxins or block sunlight from reaching other aquatic organisms. Algae are critical components of aquatic ecosystems, providing primary productivity for aquatic life, consequently their presence is important. Virus infection helps control dense algal populations by infecting the single-cells, hijacking their metabolism, and lysing the cells to release new viruses – thereby killing the cells and contributing to bloom collapse. The Chase lab is focused on unveiling interactions among eukaryotic microalgae and the giant viruses that infect and “control” them. Giant viruses house genes previously thought to be absent among viruses, and new putative functional roles are discovered frequently. We are seeking to understand the roles of giant viruses in Lake Winnipeg, their taxonomic diversity, and their impact on the lake’s microalgae. The Chase lab employs environmental sequencing to capture the microbial and viral diversity and function; extracting nucleic acid from raw water samples, sequencing, and analyzing the data via bioinformatics pipelines. We characterize the population and assess microbial genomic potential and function. The main focus of this project will be understanding the giant virus population of this large lake system, however students in the Chase lab are encouraged to explore personal interests as well. Come explore Lake Winnipeg and its giant viruses with us!
Research area, student roles & skills
Research area: The Chase lab is focused on virology, phycology, and microbial ecology and evolution. We work at the forefront of large-scale sequencing and time-series datasets by collecting aquatic samples in areas susceptible to climate change, and important to local communities which house interesting ecological dynamics. We are especially interested in virus-host relationships among bloom forming microalgae. The Chase lab specializes in understanding “giant viruses”, virophages, RNA viruses, and their impacts on the microalgae they infect. We uncover novel viruses with novel functional roles in our changing environment using in situ, in silico, and in vitro avenues.
Student roles: Successful applicants will work with Dr. Chase to formulate research questions using virus and microalgae data from Lake Winnipeg. The student’s role within the project will be to learn about giant viruses, explore their data, and report their findings. Examples of what students can explore include offshore and nearshore site differences, and microbial diversity of traditional areas of local Indigenous communities or areas of high recreational fishing and other activities. Successful applicants will collect and process water samples in-lab, and use metagenomics to provide a “shot-gun” look at all viruses contained within their samples, which they can then fine tune to identify giant viruses. Microalgal diversity and environmental roles will also be explored within the Lake Winnipeg sampling time-series. A step-by-step training on a bioinformatics pipeline through one-on-one training will ensure a thorough understanding of this skillset. Successful applicants will produce figures and tables to present their work. The goal is for successful candidates to deduce a “scientific story” to be communicated via a joint peer-reviewed publication, and/or through local community bulletins. Broadly, skills that can be obtained through this project include: field sampling, nucleic acid extraction, molecular assays, command-line bioinformatics, figure production, and scientific dissemination. Please note that field sampling is optional, students who do not wish to partake are not obligated. Students will be expected to attend weekly lab meetings to report and discuss their findings, and to partake in biweekly one-on-one meetings with Dr. Chase to advance their project and seek advice. The role of members of the Chase lab team are to contribute to an environment that is welcoming, collaborative, and scientifically motivated. In turn, Dr. Chase’s role is to provide mentorship, support the team with a safe and scientifically rigorious environment, and to facilitate the advancement of mentee career and learning goals.
Skills required: Students are required to have completed courses in or related to Microbiology. Courses on Microbial Ecology and Bioinformatics will be considered an asset, but not required. Students are required to have previous experience research experience, e.g., volunteer, research assistant, directed studies course with a research professor, or a substantial lab-based course that developed experience in molecular lab settings (i.e., sterile work environments, methods of microbiology, etc.). Other research experiences will be considered. Above all the Chase lab seeks highly motivated, and research dedicated students whose goals include all forms of scientific dissemination, and producing impactful and meaningful research.
25. Investigating the effect of timber harvesting on freshwaters
This project is a large-scale evidence synthesis of decades of research on timber harvesting’s effects on freshwaters in boreal and temperate forests. The objective of the project is to help inform forest management in freshwater habitats by identifying how different timber harvesting practices, such as buffer usage, harvest intensity, and harvest treatment, affect freshwaters. During the 12-week internship we will review scientific articles, extract and organize data from relevant articles, and compile a large dataset for analysis. The student will gain experience working with scientific literature, applying standardized data extraction methods, and managing large datasets. There will also be the opportunity for co-authorship on resulting publications, depending on the student’s level of contribution.
Research area, student roles & skills
Research area: Freshwaters are some of the world’s most ecologically and socially valuable systems but are highly vulnerable to anthropogenic disturbances. One of the most widespread anthropogenic disturbances which threaten freshwaters is timber harvesting. However, the outcomes between studies that assess timber harvesting’s impact on freshwaters are often inconsistent. These inconsistent outcomes make it difficult to determine if timber harvesting consistently affects freshwaters, and if so, what drives these effects. To address this problem, we are using evidence syntheses to quantify general trends and identify key drivers across the literature, providing a robust foundation for forest management decision-making and guiding future research.
Student roles: The student will assist a PhD candidate with an evidence synthesis investigating the effects of timber harvesting on freshwater ecosystems. The work will be done entirely at a desk and will involve: -Reading and screening scientific articles, extracting and organizing data (e.g., environmental variables, study outcomes), and helping prepare a large dataset for analysis -Extracting data from figures, tables, and supplementary materials where required Applying standardized data extraction protocols and ensuring consistency across studies (e.g., verifying entries, resolving discrepancies) -Maintaining clear documentation of data extraction decisions and coding procedures -Participating in periodic check-ins to review progress and resolve questions
The student will receive training on how to screen and extract data from scientific articles and will receive a detailed methods document to follow.
Skills required: -A background in biology, geography, ecology, physical sciences or related field -Fluent in English -Willingness to learn evidence synthesis data coding/extraction methods -Willingness to learn how to analyze complex datasets -Strong attention to detail and ability to work efficiently with large volumes of information -Experience reading and interpreting scientific literature -Ability to work independently and manage time effectively
26. Investigating the mechanism of disease for Rett Syndrome
Supervisor: Mojgan Rastegar
University: University of Manitoba (Winnipeg campus)
Background: Rett Syndrome (RTT) is a progressive neurodevelopmental disorder disorder in children. RTT patients develop normally for up to 1 year, but later exhibit loss of speech, purposeful hand movement, motor neuron impairment, scoliosis, anxiety, and mental health problems. RTT has no available cure and the mechanism of disease is still not fully understood. Methods: We have completed a multi-level analysis of the post-mortem human brain from Rett Syndrome patients and control brain tissues. Our studies include frontal cortex, cerebellum, amygdala, and hippocampus. Selection of these brain regions has been based on phenotypic symptoms of Rett Syndrome patients. Next generation sequencing has been completed at the level of DNA (for DNA methylation), RNA (RNAseq transcriptome analysis), and proteomics (protein levels). This project will focus on characterization of few short-listed genes from the three genome-wide techniques for identification of novel disease biomarkers. A combination of RT-PCR and Western blot techniques will be applied to extracted RNA and proteins from the human Rett Syndrome brain tissues, and a humanized transgenic mouse model of Rett Syndrome. Samples are already collected and are ready for RNA and protein extraction and molecular analysis. Anticipated Results: We anticipate that the short-listed genes with high abundance and detected fold change of more than 2 folds, with significant change in Rett Syndrome patients to be validated by this approach. Among these genes, the ones that show conservation between humans and mice Rett Syndrome brains could be new biomarker targets for drug therapy strategies of this disease that has no cure.
Research area, student roles & skills
Research area: My lab studies the genetic and epigenetic basics of neurodevelopmental disorders including Rett Syndrome.
Student roles: The student will be responsible for associated experiments, analyzing the data, and keeping up to date with related literature.
Skills required: Knowledge of molecular and cellular biology for transcript and protein analysis.
27. Investigation of the impact of psychotropic drugs on the gut microbiota
The gut microbiota–brain axis is a complex multi-organ bidirectional signaling system between the gut microbiota and brain that plays a crucial role in host physiology, homeostasis, development, and metabolism. Studies have shown that several mental illnesses affect the stability of gut microbiota, but the impact of psychotropic treatments on microbiota structure and metabolism remain under-explored. Psychotropic drugs have been increasingly shown to possess inhibitory properties with possible implication in microbiota-gut-brain axis. This project will investigate the real contribution of the antimicrobial effects of psychotropic drugs on gut microbiota structure and metabolism in vitro and in simulated human colon model.
Research area, student roles & skills
Research area: Our research interests are focused on the role of human microbiota as effective partner for the gastrointestinal tract. In our laboratory, we study the impact of diet and probiotics on the composition and equilibrium of gut microbiota, and the production of bioactive molecules with mental and physiological health benefits. Our goal is to modulate the human gut microbiota using next generation probiotics and their antimicrobials (bacteriocins), thus producing clinically meaningful positive changes in human health.
Student roles: - Test d'activité antimicrobienne in vitro, - Metabolic and genomic characterization of bacteria, - Analyzes and discussion of results - Assist in the preparation of culture media and materials needed for work - Maintain laboratory equipment - These tasks do not exclude a wider participation that will also allow the candidate to enrich some of his/her technical knowledge in microbiology/ molecular biology/cell biology.
Skills required: - Knowledge of molecular microbiology and biology tools (DNA extraction, PCR) - Ability to work as a team - Good sense of organization - Good interpersonal skills - Good communication - Ability to analyze scientific articles in English - Good computer skills (Word, Excel, Internet)
28. Investigation of the role of microbiota extracellular vesicles in the gut-brain axis
This research project explores extracellular vesicles production as a pathway mechanism by which microbiota interact with the gut–brain axis, as well as it is potential to restore dysbiotic gut microbiota, reach the systemic circulation, and deliver host-modulating metabolites in the brain to promote antidepressant effects.
Research area, student roles & skills
Research area: My research centers on gut microbiome physiology, its mechanistic modulation by nutritional and xenobiotic factors, and interplay with the host, and is built with around three themes: I) Gut Neuromicrobiology, 2) Interplay Xenobiotics-Microbiota-Nutrition, and 3) Investigation of new probiotic-prebiotic-postbiotic-symbiotic formulations with positive modulation of the gut microbiota and the host.
Student roles: - Biological activity in vitro, - Metabolic and genomic characterization of bacteria, - Analyzes and discussion of results - Assist in the preparation of culture media and materials needed for work - Maintain laboratory equipment - These tasks do not exclude a wider participation that will also allow the candidate to enrich some of his/her technical knowledge in microbiology/ molecular biology/cell biology.
Skills required: - Knowledge of molecular microbiology and biology tools (DNA extraction, PCR) - Ability to work as a team - Good sense of organization - Good interpersonal skills - Good communication - Ability to analyze scientific articles in English - Good computer skills (Word, Excel, Internet)
The goal of this project is to improve the sustainability of the scallop fishery in Atlantic Canada. Scallops are fished using bottom trawling, with an adjustable net size to target the minimum commercial size. Despite this, some small scallops are captured as bycatch. During the onboard sorting process, the small scallops are separated from the big ones and returned to the ocean. This process can take time, but time out of water is crucial for the survival of these small scallops. Furthermore, when they are fished, air temperature is usually different than ocean temperature. The combination of the time that the scallop is exposed to air and the temperature shock is the critical drivers that determine the survivability of the scallop. Scallop fishers in Canada would like to minimize the mortality of these small scallops, but information about how much time these small scallops can survive in the air is unknown. This project aims to determine the effect of air exposure and temperature on the survivability of small scallops, which ultimately will provide valuable information for fishers and regulators to improve management practices. The testing will be carried out at the Aquatron Laboratory at Dalhousie University, which is Canada's largest university aquatic research facility (https://www.dal.ca/dept/aquatron.html). The project will involve a strong collaboration with Fisheries and Oceans Canada, which will provide the scallops and facilitate project logistics. Given that Fisheries and Oceans are the regulators, the information generated in this project will feed back directly to the regulator, ensuring that the outcomes of this project will directly improve the sustainability of the fishing activity. Due to the lack of information on this topic and its importance to the fishing industry, it is expected that the results will be publishable in a scientific journal or as a Fisheries and Oceans Technical Report.
Research area, student roles & skills
Research area: My specialized research area is aquaculture-environment interactions, which spans a range of scales, from individual responses to interactions between cultured or fished populations and the environment. To achieve these goals, I use a range of tools, from physiological studies at the individual level to ecosystem modelling, to explore the effects of bivalve culture or fisheries on the environment, as well as how climate change can affect the performance of commercial bivalves. The ultimate goal of my research is to provide advice to managers and policymakers to improve the sustainability of aquaculture and fisheries.
Student roles: - The student will take the lead in carrying out the experiments at the Aquatron Laboratory. The experiments will include: 1) maintaining the scallops in acclimatization tanks until the experiments are carried out; 2) exposing the scallops to different air temperatures for a range of time periods (to be determined in consultation with fishers and Fisheries and Oceans Canada); 3) determining the metabolic rate and survivability of the scallops after the air exposure challenges. This will provide the student with hands-on training in seawater laboratories and experimental design. - The student will be trained in the determination of respiration rate in bivalves. Our Aquatron Laboratory is a state-of-the-art facility with the capability to measure respiration rate simultaneously in eight scallops. It is expected to have capabilities to simultaneously measure respiration on 16 scallops during the summer 2021, when these experiments will be carried out. This will provide the student with training on bivalve physiology, ranging from operating oxygen sensors, interpreting metabolic rate data, bivalve dissection. - Finally, the student will analyze the results of the experiments using the existing lab methodologies, plot results, and interpret the results. Given the novelty of these experiments, the results will be published as a primary publication or a Fisheries and Oceans Technical Report. The student will prepare the results for this publication. The student will be either a co-author or lead author on the publication, depending on their involvement. Accordingly, this will provide the student with training on scientific writing. - In summary, the student will have a leadership role in this project, and frequent interaction with the advisor will ensure the success of the internship.
Skills required: A student with a general background in biology and specific interests in animal physiology and behaviour is ideal for this project. Organizational skills, including basic knowledge of Excel, Matlab or R, would be an asset due to the need for summarizing data in tables and figures. Although the experiment is well defined, alternative hypotheses could be proposed by the student; consequently, creativity and resourcefulness will be valued. Hands-on experience caring for aquatic species will be valued. Communication skills to exchange ideas, results and brainstorm with other students/advisor are critical to be able to work both independently and collaboratively.
30. Machine Learning–Driven Community Structure and Indicator Analysis of Soil Microbial Biodiversity Across Disturbed Ecosystems
Supervisor: Yue Zhang
University: Thompson Rivers University (Kamloops campus)
oil microbial communities are sensitive early indicators of ecosystem degradation, but extracting reliable biological signals from high-dimensional, compositionally constrained amplicon sequencing data requires specialized statistical approaches. This project will apply and compare machine learning methods — including Random Forest, gradient boosting, and LASSO-regularized compositional regression — to identify indicator taxa and characterize community structure shifts across soil disturbance gradients in British Columbia. The intern will also construct microbial co-occurrence networks using compositionality-aware methods (SparCC/SPIEC-EASI) to identify keystone taxa and assess network stability. The project runs in parallel with an ongoing graduate student project in the lab, and the intern's contributions are expected to yield a co-authored manuscript submitted to a microbial ecology or environmental bioinformatics journal.
Research area, student roles & skills
Research area: My research applies advanced statistical and machine learning methods to large biological datasets, including microbial community data derived from environmental sequencing. In collaboration with Dr. Greg Anderson (Dean of Science, TRU), my lab is investigating how soil microbial biodiversity responds to ecosystem disturbance using amplicon sequencing data, compositional statistical methods, and network inference. This work connects to my expertise in LASSO-based regularization for high-dimensional biological data (Bioinformatics Advances, 2025) and is supported by an NSERC Discovery Grant (2024–2029) and a Genome BC grant (2025–2028).
Student roles: The student will conduct literature review on soil microbial ecology and compositional data analysis methods, perform statistical and machine learning analyses on amplicon sequencing datasets, assist with co-occurrence network construction and interpretation of results, and contribute to a final research report and co-authored manuscript for journal submission.
Skills required: Undergraduate degree (or final year) in bioinformatics, ecology, microbiology, statistics, or a related quantitative field Proficiency in R (phyloseq, vegan, igraph) and/or Python (scikit-learn, pandas) Familiarity with next-generation sequencing concepts; prior exposure to 16S rRNA amplicon data or microbiome analysis is a strong asset Basic understanding of ecological diversity metrics (alpha/beta diversity) and multivariate statistics (ordination methods) Experience with version control (Git/GitHub) and reproducible research workflows (RMarkdown or Snakemake)
31. Mapping the self-incompatibility locus in white clover (Trifolium repens)
White clover (Trifolium repens) is typically considered an obligately outcrossing, self-incompatible, perennial plant. White clover's self-incompatibility is known to arise from a single-locus, gametophytic self-incompatibility system whereby only pollen grains with an SI allele different from either of the ones carried at the maternal plant's SI locus can germinate and and lead to the production of fertile seed. However, this system is also known to be leaky, and recent evidence suggests a moderate frequency of self-compatible plants, which can arise via loss-of-function mutations in the SI locus, modifier loci that alter SI-locus gene action, or more complicated processes resulting from white clover's hybrid ancestry and polyploidization. What's more, the location on the self-incompatibility locus in current versions of the white clover reference genome is unknown, precluding more thorough analyses of the number of haplotypes segregating at this locus and the environmental determinants of self-compatibility in this system.
In this project, we will grow out plants from putative selfed crosses and estimate the rate of selfing in natural populations of white clover. We will leverage recent crosses and whole genome sequences from these crossed plants to identify the self-incompatibility locus in the white clover reference genome, and conduct basic population genomic analyses to infer the number of alleles segregating at this locus. We will additionally perform crossing experiments in the greenhouse to generate mapping populations with the eventual goal of providing sufficient power to identify some of the modifier loci that control SI-locus gene action in cases where the SI locus itself is still functional.
Research area, student roles & skills
Research area: I am a plant evolutionary geneticist who's work focuses on understanding phenotypic and genomic adaptation to contemporary, human-induced environmental change. My lab uses large-scale experiments with plants to understand to selective agents operating in natural plant populations, and combines this with high-throughput whole genome sequencing to uncover the genetic architecture of phenotypes driving patterns of adaptation in nature. In doing so, we leverage the latest computational advances to analyzing genomic sequencing data, and often perform simulations to understand the limits of what existing tools can do, which is especially important when working in non-model systems.
Student roles: The student will be involved in every aspect of the project. Specifically, the student will:
1. Grow out plants from recent crosses in a controlled greenhouse 2. Generate additional crosses between select plants to generate future mapping populations 3. Collect tissue for DNA extraction and library preps 4. Analyze existing genomic data from some of the parental plants that generated (1) to preliminarily identify the location of the SI locus and infer the number of segregating haplotypes given existing genomic data in this system.
This project will provide the students with a thorough understanding of how to conduct rigorous and high-throughput research in plant evolutionary genetics. The student will be the primary researcher for this project and have the freedom to make it their own. I will be around all summer and will work closely with the student on this project, meeting for at least one in-depth meeting every week.
Skills required: A background in genetics would be helpful for this project, as would experience growing plants for research, either in a controlled greenhouse, growth chamber, or in the field. A basic understanding of genomics and bioinformatics would also be helpful in the event that we get to the whole genome sequencing component of the project. Experience tracking phenotypes and collecting data on plants or animals would also be considered valuable.
32. Measuring shoreline recovery and resiliency: Biodiversity and Physical Monitoring with Watershed Stewards
This project investigates how to measure and monitor the ecological recovery and resilience of naturalized shorelines across Ontario's lake and river ecosystems. Shorelines are critical transition zones that regulate water quality, stabilize banks, filter runoff, and provide essential habitat, making their health essential to the overall function and resilience of freshwater ecosystems. Shoreline naturalization (i.e., the planting of native vegetation along water's edge) is a widely practiced nature-based solution for restoring these functions, yet standardized tools for tracking restoration outcomes remain limited. Working in partnership with a Canadian environmental charity, this project will co-produce a monitoring framework alongside landowners and community stewards that can be used to document restoration progress over time. During the 12-week internship, the student will assist in conducting field surveys at restored shoreline sites across Eastern Ontario, collecting biodiversity data (e.g., vegetation measurements and wildlife indicators) alongside physical habitat measurements (bank stability, canopy cover, substrate composition). These data will inform the development of measurable indicators of shoreline recovery and resilience, linking restored shoreline condition to broader lake and river health outcomes.
The student will also contribute to the design of landowner-facing workshops that translate monitoring findings into practical stewardship guidance, building community capacity for long-term, self-directed restoration monitoring. The ultimate goal is to provide restoration practitioners and communities with an evidence-based toolkit that strengthens the resilience and ongoing stewardship of Canada's freshwater shorelines.
Research area, student roles & skills
Research area: Freshwater ecosystems are among the most biodiverse and important ecosystems on Earth as freshwater is deeply intertwined with human activity. People rely on lakes, rivers, and wetlands for drinking water, food, recreation, and cultural connection, and in turn, human use and stewardship shapes the health of these ecosystems. Our research focuses on understanding this relationship by studying how humans interact with and care for freshwater ecosystems at the watershed scale. Alongside evaluating threats to freshwater, we develop monitoring and restoration frameworks that equip practitioners with the tools and data they need to support robust, evidence-based restoration over the long term.
Student roles: The student will participate in field work and office work during the 12 weeks of the internship, working alongside and under direct supervision of a postdoctoral research fellow. The main tasks will consist of: -Collecting biodiversity data -Measuring vegetation and environmental quality -Reviewing literature to assist in development of environmental restoration indicators -Assistance with stakeholder workshop development related to ecological restoration indicators -Report writing and design -Other opportunities that may arise from partnership with Canadian environmental charity partner
The student will receive training on field work protocols, safety, and evidence-based synthesis development.
Skills required: -Biology, ecology, or environment background -Fluent in English -Enjoys teamwork and collaboration -Exhibits high level of professionalism as project may involve meetings with external partners and landowners -Comfortable working in outdoor settings -Willingness to learn how to perform evidence-based literature review
33. Measuring the impact of a cholinergic lesion on individual approach styles
As early as Pavlov’s original conditioning experiments –in which dogs began to salivate to the sound of a buzzer that had been associated with the imminent arrival of food– researchers noticed that some animals attempted to ring the buzzer in order to obtain food. The same behaviour can be observed in other species. In rats, a non-functional lever presented to the animal before receiving food will cause some animals to press the lever, a behaviour known as "sign tracking". Other animals go for the food distributor (goal tracking), or alternate between these two behaviours. These individual styles of behaviour are observed in other species, including humans, in which sign tracking is linked to obesity.
To quantify the role of the brain acetylcholine, a neurotoxin specific to the cholinergic neurons is used to selectively lesion cells in different areas rich in cholinergic cells or cholinergic fibres. These lesions are made by brain micro-injections. The acetylcholine can play on the individual approach style by altering 1—the prefrontal cortex which is involved in top-down attention, 2—the primary visual cortex which is involved in bottom-up attention, or 3—the mesolimbic reward system which is involved in the reward evaluation. To evaluate the role of the different acetylcholine rich areas, the animal will be compared before and after the cholinergic lesion by the measure of their individual approach behaviour in a Skinner box. These results will establish which part of the behaviour is under the cholinergic system influence.
Research area, student roles & skills
Research area: My laboratory is specialized in: neuroscience, behaviour, immunohistochemistry, rat, brain, reward system, surgeries and electrophysiology.
Student roles: The student will take the rats and place them in Skinner's box to run tests. Verify that every Skinner box is working properly. After the test, clean the Skinner box and retrieve the data for later analysis. We have to run several batches of rat each day. The student will take good care of the rats, change litters, and insure water and food are available to the animals. Stereotaxic lesions will be made by injecting a neurotoxin in precise brain area, students are expected to learn to do these surgeries. Histologic analysis of the injection site will be performed. After this surgery animal will recover then be retested in the Skinner box. Students are going to analyze the data and produce a report on those results.
Skills required: Bases in biology and psychology. Have taken a class like psychobiology, or neuroscience. Being good with animals in general. Previous experience with rat is not mandatory but the student will have to pet rat every day. Rat, blood and syringe should not be something scary for you.
34. Medium Optimization for Enhanced Growth of Engineered E. coli
The optimization of growth medium is essential for maximizing the productivity of (genetically modified) microbial strains. This project will evaluate different cultivation conditions using engineered Escherichia coli strains to identify the most effective strategies for enhancing bacterial growth rates. Different key parameters such as nutrient concentrations present in the medium will be tested using a design of experiment. Besides the experimental work, the candidate will learn how to implement predictive models developed in Python, employing statistical regression or machine learning techniques (e.g., regression trees, neural networks) to analyze experimental data and predict optimal growth conditions During the internship, the selected candidate will gain hands-on experience in microbial cultivation, analytical methods (optical density, cell counting, metabolite assays), and statistical analysis. Insights from the experiments will directly influence the scalability and economic viability of the process involving engineered microorganisms. This project is suitable for students passionate in research related to biotechnology, microbiology, and biochemical engineering.
Research area, student roles & skills
Research area: Our research group specializes in modelling and experiments of sustainable technologies aiming at reducing the environmental impact of chemical and biological processes. Some applications of interest include, but are not limited to, bio-hydrogen production, conversion of captured CO2 to synthetic fuel, and cell cultures production. Modelling tools, including data-driven methods, are integrated with experimental data analysis to optimize production efficiency.
Student roles: The selected candidate will work on an independent project under the assistance of graduate students and the supervision of the professor. Literature review would be the first step, followed by the experiments design and development. The student will be part of a dynamic research team, will attend weekly meetings to track progress, learn from other group members, disseminate results and get some feedback and support. According to the findings, the student will have the opportunity to present the project in a national conference and/or to write a paper
Skills required: Ideal candidates are students in biotechnology, microbiology, bioengineering, or related fields. The student should be detail-oriented, analytical, and comfortable working in laboratory settings, and posses problem-solving capabilities. Basic knowledge of microbiological techniques (cultivation) and data analysis tools (Excel, Python) is desirable but not essential
35. Monitoring red squirrels in the Canadian Arctic
This project contributes to a long-term, individual-based study of North American red squirrels (Tamiasciurus hudsonicus) in the boreal forests of the Kluane region of southwest Yukon, one of the most intensively studied small mammal systems in the world. Red squirrels in this population are individually marked and followed across their entire lives, offering a rare opportunity to ask how individual variation in behaviour and movement shapes ecological and evolutionary outcomes in a wild mammal under realistic environmental conditions. The intern will join an active spring and early summer field campaign collecting data on territoriality, reproduction, and behaviour during a peak period of the annual cycle, when reproductive activity are at their highest. Data collected during the internship will directly support ongoing graduate research in the lab, contributing to questions about how consistent individual differences in behaviour influence fitness, how animals make movement and settlement decisions on heterogeneous landscapes, and how those decisions translate into population-level patterns. The Kluane system offers a unique combination of long-term continuity, individual-level resolution, and a relatively intact boreal ecosystem, making it an unparalleled training environment for an aspiring ecologist. The intern will work alongside graduate students, field assistants, and the supervisor at a remote field camp, learning standardized field protocols, the natural history of the system, and the principles of long-term population studies. Beyond data collection, the intern will be exposed to the broader scientific questions motivating the work and will have opportunities to discuss study design, hypothesis testing, and analysis with team members. The internship is designed to give a strong scientific and practical foundation for students considering graduate studies in ecology, behaviour, or evolutionary biology.
Research area, student roles & skills
Research area: Our lab investigates movement ecology, behavioural ecology, and wildlife ecology, with a focus on how individual variation in behaviour, personality, and space use shapes ecological and evolutionary outcomes in wild animal populations. We work primarily with small mammals in northern systems, combining intensive long-term field studies of individually marked animals with quantitative analyses of movement, social structure, and life history. A central question driving our work is why individuals within the same population behave so differently, and what the consequences of that variation are for survival, reproduction, and population dynamics. We integrate field-based data collection with statistical and theoretical approaches.
Student roles: The student will be a full member of the field team for the duration of the 12-week internship, working 40 hours per week alongside the supervisor, graduate students, and other field assistants at a remote field camp in the Kluane region of the Yukon. The position has a firm start date of May 1, 2027, as peak data collection in this system occurs in April and May, and the student must be on site from day one of the program window. Day to day, the student will live-trap red squirrels using standardized protocols, including setting and baiting traps, checking trap lines on assigned grids, safely handling captured animals, applying ear tags, taking biometric measurements, and recording data in the field. The student will conduct territory and behavioural surveys, listening for and mapping vocalizations, identifying individually marked animals, and recording behavioural observations using focal and scan sampling. They will track individuals using radio-collars, contributing to ongoing movement and space-use research. Each evening, the student will enter, clean, and quality-check the day's field data, and will help maintain field gear, traps, and shared camp infrastructure. Beyond direct data collection, the student will participate in regular team discussions about study design, observations from the field, and the broader scientific questions driving the work, and will be encouraged to ask questions, develop hypotheses, and take ownership of small aspects of data collection. The student is expected to follow all safety protocols, including bear safety, and to communicate openly with the supervisor and team about any concerns. By the end of the internship, the student should have a foundational toolkit of small mammal field skills and a strong sense of what long-term ecological research looks like in practice.
Skills required: The ideal candidate is an undergraduate in ecology, biology, wildlife science, or a related discipline, with a strong work ethic, attention to detail, and willingness to follow standardized protocols. Prior backcountry or wilderness experience is required, as the work takes place at a remote field camp under rustic conditions in true wilderness without electricity, heating, or running water. The student must be physically fit for long days of off-trail hiking while carrying gear, and able to live and work cooperatively in close quarters with a small team. Small mammal handling or telemetry are assets but not required.
36. Optimization of Anaerobic Digestion for Green Gas and Biomethane Production from Novel Organic Substrates.
This 12-week research project is embedded within a circular economy framework aimed at transforming organic waste into high-value energy resources. The main objective is to experimentally investigate biomass valorization through anaerobic digestion to maximize green gas and biomethane production. Given the concise timeframe, the project focuses on execution, data tracking, and laboratory validation.
The intern will actively participate in laboratory-scale trials to assess the biochemical methane potential (BMP) of novel organic substrates. This practical approach is essential to understand degradation behavior and biological kinetics under realistic operational conditions. The student will handle the experimental setup, monitor daily gas production, and track crucial process parameters.
Operating within a multidisciplinary and international team at BTL, the intern will contribute directly to gathering critical empirical data required for process scalability. The outcomes of this short-term project will provide immediate, reliable validation of methane yields from new biomass streams. Through this intensive internship, the student will acquire hands-on laboratory expertise in cutting-edge anaerobic systems, experimental protocols, and biochemical analytics, essential fields for the developing bioenergy sector.
Research area, student roles & skills
Research area: The Biomass Technology Laboratory (BTL) offers a unique research window dedicated to valorizing diverse sources of residual carbon and solving food industry challenges. For over a decade, BTL has pioneered the conversion of lignocellulosic and organic residues into simple sugars, biofuels, and high-value biosourced chemicals. Our strategic areas include the thermochemical and biochemical conversion of biomass, the deployment of cutting-edge bioprocesses (such as anaerobic digestion and fermentation), and the chemical valorization of renewable electricity using CO2 as a carbon source. BTL integrates rigorous data processing, process optimization, and extensive analytical expertise to drive the global bioeconomy forward.
Student roles: During the 12-week internship, the student will be responsible for conducting anaerobic digestion laboratory experiments. To foster integration into our international team, the intern will start by delivering an initial presentation about their academic background and proposed internship goals. Core responsibilities include preparing organic substrate samples, monitoring biochemical methane potential (BMP) reactors, and performing physical-chemical analyses. The student will meticulously log daily biogas production data into structured spreadsheets. Additionally, the intern will participate in laboratory maintenance, attend team meetings, and present a final synthesis of their experimental results to the BTL research group.
Skills required: Candidates should be undergraduate or graduate students in Chemical Engineering, Biochemical Engineering, Biotechnology, Chemistry, or a related discipline. Applicants must demonstrate strong hands-on skills and prior experience working in wet chemistry or biology laboratories. Familiarity with basic analytical techniques (such as titration, spectrophotometry, or chromatography) and standard laboratory safety protocols is highly valued. The role requires rigorous organizational abilities to handle multiple experimental samples simultaneously, a collaborative mindset for multidisciplinary team integration, and professional proficiency in either English or French.
37. Optimization of Mammalian Cell Culture via AI-driven Analysis
Optimizing mammalian cell culture processes is critical for biopharmaceutical and therapeutic applications. This project aims to investigate the effects of relevant growth parameters on mammalian cell health and productivity, using AI tools developed in our lab. You will explore factors such as nutrient availability (e.g., glucose) and culture conditions (e.g., dissolved oxygen, pH), evaluating their impact on cell viability, proliferation, and metabolic profiles. Leveraging AI-driven analytical approaches, you will analyze complex data sets generated through cell culture experiments, developing predictive models to finally determine optimal conditions. This project provides hands-on experience with cell culture techniques, data analytics, and AI-driven predictive modeling, empowering you to contribute significantly to improvements in cell culture performance. The cell type will be selected at the beginning of the project. Students passionate about biotechnology, cellular biology, AI integration, and bioprocess optimization can strongly benefit from this interdisciplinary project.
Research area, student roles & skills
Research area: Our research group specializes in modelling and experiments of sustainable technologies aiming at reducing the environmental impact of chemical and biological processes. Some applications of interest include, but are not limited to, bio-hydrogen production, conversion of captured CO2 to synthetic fuel, and cell cultures production. Modelling tools, including data-driven methods, are integrated with experimental data analysis to optimize production efficiency.
Student roles: The selected candidate will work on an independent project under the assistance of graduate students and the supervision of the professor. Literature review would be the first step, followed by the experiments design and development. The student will be part of a dynamic research team, will attend weekly meetings to track progress, learn from other group members, disseminate results and get some feedback and support. According to the findings, the student will have the opportunity to present the project in a national conference and/or to write a paper.
Skills required: Ideal students will have a background in biotechnology, bioinformatics, cellular biology, or biomedical engineering. Experience with mammalian cell culture techniques, basic analytical assays (viability, cell counting), and familiarity with data analysis tools or programming (Python, R) would be advantageous. The candidate should demonstrate interest in interdisciplinary research, combining laboratory experimentation with AI-based analysis. Strong analytical skills, curiosity about machine learning applications in biology are relevant.
38. Paleo-floods and paleo-fires in the Ottawa River Valley
Supervisor: Jeannine-Marie St-Jacques
University: Concordia University (Montréal campus)
Severe spring snowmelt flooding occurred in 1974, 1976, 2017 and 2019 in the Ottawa
River Basin (ORB). The floods of 2017 and 2019 resulted in the evacuation of ~14,000
persons and governmental costs of ~$1 billion. Regional flood management in the
densely populated ORB could be improved by long-term flood records for naturally-flowing tributaries of the Ottawa River. Unfortunately, the regional flood instrumental
records are very short, beginning at best in ~1910. There are few streamflow gauges in the northern headwaters forming two-thirds of the ORB. Almost all of these few gauges
are on regulated tributaries, with regulation beginning at the same time as the records,
producing contaminated data. However, to better manage ORB floods, we need better
long-term data of natural flood risks. Regional flood management in the ORB and its environs would be improved by long-term flood records, i.e. multi-centennial to
millennial length records, derived from paleoenvironmental methods. In these methods,
floods are reconstructed from oxbow lake sediment cores. During floods that connect a
river with an oxbow lake, the lake traps sediment from the floodwater suspended load. The composition of floodwater sediments typically differs from locally sourced sediment deposited during non-flood conditions, in grain size distribution, sediment sources or proportion of organic matter. Hence, by taking sediment cores from oxbow lakes, dating them, and analyzing them for past sediment changes, one can infer past floods. Such paleo-flood reconstructions would provide us with longer-term flood frequencies and
intensities and whether there are emerging trends in ORB floods. An important related question is how much has European land clearance in the ORB contributed to changes
in regional flooding over the last 200 years.
Research area, student roles & skills
Research area: I am a paleoclimatologist who infers environments of the past two millennia in
North America at high-resolution. I reconstruct past climates, river flows, floods,
fires, forests and aquatic environments using a mix of proxies: pollen, charcoal, diatoms,
particle size analysis, and x-ray fluorescence in lake and bog sediments, and tree-ring
thicknesses. If we want to understand how the environment is changing around us, we
must understand baseline natural conditions before large human populations and the
industrial era perturbed most regions. This inference of past baselines is what my
research aims to produce.
Student roles: The student will either undertake a study of paleo-fires in the Ottawa River Valley or do loss-on-ignition (LOI) analysis of sediments from the valley. For the first, they will use the same dated sediment cores that are already being used in the paleo-flood study. Fires release micro-particles of charcoal into the air. These particles are carried by winds and water and deposited in lakes. By sampling a lake sediment core and counting and measuring the surface area of the charcoal particles in each sample, one can infer a past record of fires around the lake. A dissecting microscope with a camera and computer attached are used to do this analysis. This analysis will allow us to examine if there exists a relationship between fires and floods in the basin. It will also allow us to determine baseline pre-European fire frequencies for several sub-basins. Southwestern Quebec is the driest region in Quebec and is expected to be severely impacted by anthropogenic climate change. Hence, having pre-industrial area fire frequencies will be useful. Alternatively, the student might also help in doing a LOI analysis of the already taken lake sediment cores. In LOI analysis, volumetric samples are burnt at fixed temperatures for fixed times and then weighed. First, organic material is burnt off at 550oC, then carbonates at 950oC. By weighing the samples after each burn, one can deduce the amount of organic material, carbonates and silicates in each core. This analysis allows us to detect changes in sediment material and hence source areas in the cores. If the opportunity arises and the student is willing, the student will also assist in fieldwork in Quebec, either taking lake or peat bog cores, or coring trees. Quebec is gorgeous in the summertime. It is good to get out of the city.
Skills required: The student will have some background in geography, earth science, environmental science, forestry, botany or biology. I provide all lab training. The student will need to be careful and diligent in their lab work and show close attention to detail. They will be curious and able to work semi-independently. Some fieldwork experience or at least an interest in trying fieldwork is an asset. Computer skills are also an asset, including GIS, R or Matlab. Patience with cranky scientific software and equipment is a must.
39. Personalized combination therapies in breast and ovarian cancer
Breast cancer and ovarian cancer are respectively the 2nd and 5th deadliest cancers in women, partly due to limited therapeutic options. Our laboratory aims at developping new personalized therapeutic approaches for patients. This project aims to investigate the adaptive mechanisms triggered in response to PARP inhibitors; a targeted agent offered to patients with defects in DNA damage repair. We will test different therapeutic combinations targeting these tumor survival mechanisms to develop a personalized treatment platform capable of predicting the most effective PARPi-based treatment for each patient. The mitacs globalink intern will participate in the culture and experimentation on patient-derived organoids and will be trained in drug synergy studies, bulk and spatial single-cell proteomic. This internship will allow the development of skills in molecular biology, cell culture, and data analysis within a translational oncology research context.
Research area, student roles & skills
Research area: Our laboratory works on the development of personalized therapies in breast and ovarian cancers. We employ longitudinal multiomics analysis of clinical and pre-clinical samples to identify therapeutic vulnerabilities and therapeutic opportunities.
Student roles: The student will work with cell lines and will test different drugs in viability assay. The student will also do several cell biology assays such as western blots, PCR, IF, etc.
Skills required: Knowledge in cell biology is required and a good understanding of cancer biology is preferable.
40. Plant ecology and restoration of metal-contaminated wetlands in Sudbury, Ontario
Supervisor: Ellie Goud
University: St. Mary's University (Halifax campus)
Sudbury, Ontario is one of the world's largest metal mining centres, and historically has been the largest global point source of sulphur dioxide and metal particulate pollution from copper and nickel mining. We aim to develop novel restoration techniques to address the impacts of industrial contamination on peatlands. Peatlands are terrestrial wetlands that play a vital role in combatting global climate change by acting as long-term carbon sinks. Currently there are no methods for restoring metal-contaminated peatlands. This proposed research will contribute to novel restoration techniques with the larger goal of achieving net zero carbon within the region, and broadly in Canadian mining-impacted landscapes.
The research project combines techniques and expertise in hydrology, biogeochemistry, plant, soil and microbial biology. This position is part of the plant biology research team led by Dr. Ellie Goud, and will determine impacts of metal contamination on plant growth and physiology in order to inform restoration trials. The field season from May – August will involve extensive field and plant growth studies to measure plant diversity and environmental variables in peatland sites with increasing levels of metal and sulphur contamination, including sites being restored. The intern will have the opportunity to travel to Ontario for field work.
Research area, student roles & skills
Research area: The Goud Lab asks fundamental and applied questions in plant biology and ecology. Our research addresses how variation in plant function influences patterns of biodiversity and ecosystem function, and how we can use this information to solve environmental problems. Current research focuses on plant responses and adaptations to abiotic stressors such as soil acidity, salinity, and metal contamination, and how this information can be applied to restore degraded ecosystems. We use interdisciplinary methods to answer our research questions, including plant traits, stable isotopes, leaf gas exchange, and environmental measurements.
Student roles: The student will participate in all aspects of the measurement program. This includes plant, water, and soil measurements. The student will participate in field trips to wetland sites in Sudbury, Ontario. The student will work as part of larger team, receiving training from professors, professional scientists, and other students in all field sampling.
Skills required: This is a field assistant position, and the student will be spending a lot of their time outdoors conducting field measurements. Training in specific field skills will be provided for the student, including plant species identification, plant trait measurements, soil and water sampling and analyses. A background in ecology, plant biology, physical geography, hydrology, ecological or environmental chemistry, soil science or a related field is required. Field work experience, lab experience, or hobbies that involve outdoor activities are an asset. We are looking for someone who is excited about being outdoors and who works well in a team.
41. Producing value-added bioproducts in yeast via metabolic engineering and fermentation
Supervisor: Guanqun(Gavin) Chen
University: University of Alberta (Edmonton campus)
We have two ongoing projects on producing value-added bioproducts in yeast via metabolic engineering and fermentation. The students will conduct research with a postdoctoral fellow and getting hands-on training. One project focuses on genome editing and synthetic biology, and the other project focuses on fermentation optimization.
Research area, student roles & skills
Research area: The global demand for vegetable oils is rising for use in food, biomaterials, and biofuels. Enhancing seed oil production and customizing oils can boost Canada’s economy and diversify markets. Certain microorganisms also produce valuable lipids. However, improving oil yield and quality remains challenging due to limited knowledge of biosynthesis. Our research focuses on (1) expanding understanding of storage lipid formation, (2) increasing oil yield in plants and microbes, producing high-value bioproducts via synthetic biology, and (3) improving agronomic traits of canola like stress tolerance, seed yield, and oil quality to ensure stable, sustainable oil crop production amid environmental variability.
Student roles: The students will conduct research with postdoctoral fellows and get strong hands-on training. The students need to follow advice.
Skills required: Demonstrated strong knowledge and course scores in metabolic engineering, molecular biology, and applied microbiology. Previous research experience in labs is advantageous. Excellent organizational abilities and communication skills (both written and verbal) are essential, as is a proven capacity for effective collaboration.
42. Regulation of oncogenic tyrosine kinase receptors signalling
Signalling pathways downstream of receptor tyrosine kinases (RTKs) are essential for organogenesis and homeostasis. In humans, activation of RTKs at inappropriate locations or times can have disastrous consequences such as cancer. This has made many RTKs prime targets for drug development. Signals from RTKs are often relayed via effectors containing modular protein binding domains, which are instrumental for the assembly of multidimensional signalling networks. Adaptor proteins are prototypical examples of such effectors. Adaptors serve as hubs to recruit appropriate target proteins and to guide signals along specific pathways. They allow a relatively small number of receptor-ligand combinations to produce a wide range of outcomes depending on cell type and environment. However, the molecular mechanisms underlying such diversity are poorly defined, as it remains unclear how different RTKs share the same adaptor proteins, yet recruit various combinations of regulatory proteins to produce outcomes specific to each RTK. We discovered a novel mechanism by which RTKs terminate downstream signalling while still remaining on the plasma membrane in a catalytically active state. We found that this mechanism is independent of receptor recycling and rather involves the direct phosphorylation by RTKs of SH3 domains. This phosphorylation occurs on an evolutionary-conserved Tyr present in the majority of the >250 human SH3s of signalling proteins. This published finding led us to hypothesize that RTKs utilize tyrosine phosphorylation of SH3 domains on downstream effectors to dynamically sculpt the composition of the signalling complexes that they nucleate when activated. The proposed research project will focus on the definition of the selectivity and efficiency of RTKs towards SH3 domains.
Research area, student roles & skills
Research area: Our main goal is to decipher how normal cells establish a specific response to given extracellular cues, and to further define how this is deregulated in cancer cells. To achieve this, our work seeks to determine how signalling networks are formed in normal cells and how different they are in cancer cells. We are using a combination of state-of-the art approaches in protein biochemistry, cell biology, microscopy and proteomics.
Student roles: The student will work on a small-scale project that is related to the work of a postdoc in the laboratory. The student is expected to learn how to perform molecular biology, biochemistry and cell biology experiments related to proteins in a cutting-edge life science research environment. The student is expected to be able to perform experiments independently by the end of the internship. The student will design and execute protocols, perform experiments, analyse data and report them (figures, tables, short reports) to the team. The lab is composed of 6-8 people from all over the world, at different stages of their career.
Skills required: The student must have a basic knowledge in biology/biochemistry, with at least some laboratory experience. The student is expected to be motivated, meticulous, and to have positive interactions with the team.
43. Screening and characterization of bacterial strains with high neurobiological potential from human intestinal microbiota
Recent scientific studies have reported that dysbiosis of the intestinal microbiota can play a major role in the development of depressive behaviors. The psychobiotic probiotics can positively influence the microbiota-brain interactions. Nowadays, there is some clinical evidence to support a role of probiotics in reducing anxiety, decreasing stress responses and improving mood in persons with metabolic diseases. Gut bacteria and probiotics produce through fibres metabolism a range of neurotransmitters, including dopamine, γ-aminobutyric acid, serotonin, noradrenaline, and acetylcholine. Some of these neurotransmitters could regulate many intestinal physiological functions, such as intestinal fluid secretion, blood circulation and ulceration. Despite some studies, the mechanisms by which these probiotics are able to exert these beneficial effects on the digestive tract and to modulate the intestinal microbiota are far from being elucidated and remain very hypothetical. Although there is no direct evidence to date, it is likely that these neurotransmitters produced by intestinal and probiotic bacteria modulate synaptic activity in proximal neurons of the enteric nervous system, and thus constitute an important avenue for future research. The trainee(s) will carry out laboratory activities to isolate new intestinal strains and evaluate their probiotic potential.
Research area, student roles & skills
Research area: Our research interests are focused on the role of human microbiota as effective partner for the gastrointestinal tract. In our laboratory, we study the impact of diet and probiotics on the composition and equilibrium of gut microbiota, and the production of bioactive molecules with mental and physiological health benefits. Our goal is to modulate the human gut microbiota using next generation probiotics and their antimicrobials (bacteriocins), thus producing clinically meaningful positive changes in human health.
Student roles: - Isolation of intestinal bacteria, - Metabolic and genomic characterization of isolated bacteria, - Analyzes and discussion of results - Assist in the preparation of culture media and materials needed for work - Maintain laboratory equipment - These tasks do not exclude a wider participation that will also allow the candidate to enrich some of his/her technical knowledge in microbiology/ molecular biology/cell biology.
Skills required: - Knowledge of molecular microbiology and biology tools (DNA extraction, PCR) - Ability to work as a team - Good sense of organization - Good interpersonal skills - Good communication - Ability to analyze scientific articles in English - Good computer skills (Word, Excel, Internet)
44. Study of the therapeutic potential of oncolytic viruses against ovarian cancer
The 5-year overall survival rate for patients diagnosed with advanced-stage ovarian cancer remains as low as 30%. When patients develop an antitumor immune response during treatment, their prognosis tends to improve significantly. Harnessing this immune response could therefore lead to better clinical outcomes. Oncolytic viruses are viruses that replicate specifically in cancer cells. In addition to killing cancer cells, they have demonstrated strong potential to activate antitumor immunity. However, no oncolytic virotherapy has yet been successfully developed to both selectively eliminate cancer cells and effectively stimulate the immune response in ovarian cancer. This study aims to evaluate the therapeutic potential and immunomodulatory capacity of different genetically modified oncolytic viruses in the context of ovarian cancer treatment.
Research area, student roles & skills
Research area: Our laboratory works on the development of personalized therapies in ovarian cancer. We employ longitudinal multiomics analysis of clinical and pre-clinical samples to identify therapeutic vulnerabilities and therapeutic opportunities.
Student roles: The student will work with cell lines and will test different drugs in viability assay. The student will also do several cell biology assays such as western blots, PCR, IF, etc.
Skills required: Knowledge in cell biology is required and a good understanding of cancer biology is preferable.
45. Suivi écologique du biocontrôle du Phragmites australis et inventaires floristiques sur sites miniers abandonnés en Abitibi-Témiscamingue
Supervisor: Simon Taurines
University: Université du Québec en Abitibi–Temiscamingue (Rouyn-Noranda campus)
Ce projet s’inscrit dans un programme de recherche visant à développer des approches innovantes de restauration écologique sur les sites miniers abandonnés en contexte boréal. Il porte sur le suivi d’une stratégie expérimentale de biocontrôle du Phragmites australis subsp. australis (roseau commun), une plante exotique envahissante qui colonise de nombreux milieux humides perturbés, y compris d’anciens sites miniers en Abitibi-Témiscamingue, au Québec.
Depuis 2026, un dispositif expérimental est en place afin d’évaluer la faisabilité de l’utilisation d’Archanara spp., un lépidoptère hôte exclusif de P. australis, dont la larve peut agir comme agent potentiel de biocontrôle pour réduire la vigueur du roseau commun et favoriser le retour de la végétation indigène. Le projet de stage proposé vise à assurer le suivi écologique de ces interventions sur le terrain.
La personne stagiaire participera à l’évaluation de l’établissement du biocontrôle, au suivi de la réponse de la végétation et à la réalisation d’inventaires floristiques sur plusieurs sites miniers abandonnés. Ces inventaires permettront de documenter la présence, l’absence et, lorsque pertinent, le recouvrement du Phragmites australis à l’échelle régionale.
Ce projet permettra de mieux comprendre la dynamique d’envahissement du roseau commun en contexte minier et d’identifier des stratégies de gestion compatibles avec les objectifs de restauration écologique. Les résultats générés contribueront à orienter les pratiques de restauration des sites miniers et la gestion des espèces envahissantes au Québec.
Research area, student roles & skills
Research area: Je mène des recherches en restauration écologique des sites miniers en contexte boréal, avec un intérêt particulier pour les dynamiques de végétation, les espèces exotiques envahissantes et le réensauvagement des milieux perturbés. Mes travaux visent à comprendre comment les écosystèmes miniers se régénèrent naturellement ou à la suite d’interventions de restauration, afin de développer des approches durables favorisant le retour de la biodiversité et des fonctions écologiques. J’utilise des approches de terrain combinées à l’écologie végétale, à l’analyse de la biodiversité et à l’étude des interactions plante-sol, en partenariat avec l’industrie et des acteurs gouvernementaux.
Student roles: La personne stagiaire participera activement aux activités de terrain, de suivi écologique et de traitement de données associées au projet. Son rôle principal consistera à assurer le suivi des efforts de biocontrôle du Phragmites australis entrepris dans le cadre des travaux amorcés en 2026 sur plusieurs sites miniers abandonnés en Abitibi-Témiscamingue. Elle contribuera au suivi des parcelles expérimentales, incluant l’observation de l’établissement des agents de biocontrôle, l’évaluation de la vigueur du Phragmites australis et la documentation de la réponse de la végétation environnante. Des visites de terrain sur différents sites miniers abandonnés permettront également de réaliser des inventaires floristiques visant à documenter la présence, l’absence et le recouvrement du Phragmites australis dans différents contextes écologiques. Le stage comprendra aussi des activités de cartographie et d’acquisition de données spatiales. La personne stagiaire participera à des vols de drone pour la production d’orthophotographies de certains sites, ainsi qu’à la délimitation de colonies de Phragmites sur le terrain à l’aide d’un système GNSS RTK. Ces données serviront à produire des polygones spatialisés et à documenter la distribution de l’espèce. La personne étudiante prendra également part à l’organisation, au traitement et à l’analyse des données recueillies, incluant la gestion de bases de données, l’analyse exploratoire et l’utilisation d’outils de systèmes d’information géographique (SIG). Le stage offrira une formation appliquée en écologie végétale, inventaires botaniques, géomatique et restauration écologique en contexte minier.
Skills required: Nous recherchons une personne étudiante inscrite en biologie, écologie, foresterie, entomologie ou dans une discipline connexe, ayant un intérêt marqué pour l’écologie de terrain et la recherche appliquée. Une expérience en inventaires floristiques, en suivi écologique ou en travail de terrain constitue un atout. La personne devra faire preuve d’autonomie, de rigueur scientifique, d’un bon esprit d’observation et d’une capacité à travailler en équipe dans des conditions de terrain variables. Une aisance à communiquer en anglais est souhaitée dans le cadre des collaborations du projet (collaboration avec l'Université de Toronto).
46. The Use of Metacognitive Assignments in a Learning Management System to Improve Summative Assessment Outcomes in Introductory Biology
Supervisor: Robert Deziel
University: University of Prince Edward Island (Charlottetown campus)
The proposed research project will be investigating the role of metacognitive questioning in supporting student success in STEM, specifically in the context of a first-year undergraduate biology course. In brief, metacognitive questions are prompts that encourage students to reflect on their own learning and to identify gaps in their understanding, with the ultimate goal of aiding the student discover what they need to work on to improve their knowledge of course material. Although there is evidence that metacognitive awareness can be a strong predictor of academic achievement, its integration into STEM pedagogy remains limited.
The proposed project seeks to address this gap by designing and deploying a structured metacognitive questioning framework within an established Learning Management System (LMS) familiar to the students. Through this LMS, undergraduate students enrolled in BIO 1320 - Organisms and Environment will be prompted weekly with targeted metaquestions designed to elicit reflection on their comprehension of the material that was presented during class that week. Questions will also be administered at other key points in the semester to capture longitudinal data on students' evolving self-assessments.
A central aim of the project is to identify which areas of course content students consistently find most challenging, and to examine whether regular engagement with meta questions correlates with improvements in academic performance. Data collected through the LMS will be analyzed using both quantitative measures, including assessment outcomes from their midterm grades and final exam grade, and qualitative methods, such as thematic analysis of open-ended student responses. Findings from this project are expected to contribute to the broader literature on metacognition and biology education while generating practical insights for other instructors who may wish to embed self-reflective practices into their classroom.
Research area, student roles & skills
Research area: The research area of my lab is to examine the Scholarship of Teaching and Learning (SoTL) in the sciences, specifically in the early undergraduate teaching of biology. My research focuses on understanding, testing, and examining teaching and learning strategies that may help students better understand fundamental ideas in biology. This includes investigating different pedagogical approaches, testing a variety of active learning techniques, and deploying alternative assessment methods that may promote better conceptual understanding of difficult biological concepts. My work aims to identify and implement strategies that improve student engagement, retention, and success in introductory biology courses at the undergraduate level.
Student roles: The student working on this project will be responsible for analyzing the data collected through the LMS-based metacognitive questioning intervention administered to the undergraduate students enrolled in BIO 1320 - Organisms and Environment. This will involve examining the dataset of students' weekly self-assessment responses, along with responses collected at other key points in the semester, to identify which areas of course content students consistently found most challenging.
The student will also investigate whether regular engagement with the metaquestions correlates with improvements in academic performance, drawing on quantitative measures such as midterm and final exam grades. In addition, the student will conduct qualitative analysis, including thematic analysis of open-ended student responses, to better understand patterns in how students engaged with the reflective prompts.
Ultimately, the student's analysis will focus on assessing whether this metacognitive questioning framework was an effective method of supporting student learning, with the goal of contributing practical insights on its value as an instructional tool for STEM educators.
Skills required: The preferred candidate should have the following skills and background:
Background: - Be pursuing a science or education undergraduate degree. - An interest in science education and science outreach
Skills: - Basic statistical analysis skills (comparison of means, regression analysis, correlational analysis, etc.) - Experience with statistical analysis tools such as R, SPSS, or Minitab - Strong organizational skills for managing a longitudinal dataset collected at multiple time points - Ability to maintain confidentiality and handle student data in accordance with our institution's REB policies and guidelines
47. The effects of forest disturbances on lotic food-webs and riparian insectivory
This project will produce a systematic evidence map to synthesize and characterize existing research on how stand-reducing forest disturbances influence aquatic-terrestrial linkages in riparian ecosystems. Specifically, we examine how timber harvest, wildfire, and insect outbreaks affect benthic invertebrate communities, the emergence of adult aquatic insects, and the riparian and aquatic insectivores.
During a 12-week internship the applicant will assist in extracting and coding information on geographic distribution, ecosystem type, disturbance characteristics (type, severity, extent), taxa studied, and the mechanisms linking disturbance to ecological responses. Further they will classify whether studies assess direct effects or indirect pathways mediated by biotic (e.g., food webs, primary producers, benthic communities) or abiotic factors (e.g., nutrients, organic matter, hydrology). They will also document study design features, including replication, temporal scale, and inclusion of environmental covariates.
During the internship, the student will also have the opportunity to assist in other lab work associated with this field of research. One such opportunity will be to assist in the taxonomic categorization of adult aquatic insects collected in streams affected by spruce budworm.
Research area, student roles & skills
Research area: Riparian forests are especially important for aerial insectivores, providing terrestrial and aquatic emergent insect prey. Stand-reducing forest disturbances can reshape aquatic insect communities, especially when they affect riparian forests. For example, disturbances such as timber harvest, wildfire, and insect outbreaks alter the physical, chemical, and nutrient inputs into streams, often increasing primary productivity and leading to shifts in benthic invertebrate communities. While benthic invertebrate responses to forest disturbances are well documented, links between these responses and the community structure of their emergent adult terrestrial life stages and the insectivores that consume them, are not.
Student roles: During the 12-week internship, the student will participate in both office-based research and collaborative lab activities under the direct supervision of a PhD student. The primary focus of the role will be to support the development of a systematic evidence map.
Key responsibilities will include: -Extracting and coding data from peer-reviewed literature, including information on geographic distribution, ecosystem type, disturbance characteristics (e.g., type, severity, extent), taxa studied, and ecological responses. -Classifying whether studies assess direct effects or indirect pathways mediated by biotic factors (e.g., food webs, benthic communities) or abiotic drivers (e.g., nutrients, hydrology) -Documenting study design features such as replication, temporal scale, and environmental covariates. -Contributing to the literature synthesis processes following established evidence synthesis protocols -Assisting in organizing and summarizing findings for reporting. -Training will be provided in evidence-based synthesis methods, data management, and relevant ecological concepts.
Skills required: -Biology, ecology, or environment background -Fluent in English -Enjoys teamwork and collaboration -Exhibits high level of professionalism -Comfortable with learning evidence-based literature review -Experience reading or reviewing scientific literature
We recently developed a microscope and image-analysis pipeline that let us, for the first time, simultaneously measure the mass of single live bacteria and cell shape with unprecedented precision in live cells [see vanteeffelenlab.org for details]. A major goal of our lab is to understand how cells coordinate growth of cell shape with growth of biomass to maintain a high degree of intracellular macromolecular crowding, one of the key functions of cell-envelope growth. In this project the student will perturb different processes of biomass growth (metabolism) and envelope growth (e.g., membrane biosynthesis) while measuring biomass and shape growth. Depending on the experience in either biology, physics, or engineering, the project will either involve the construction and investigation of mutants or the modulation of the microscope.
Research area, student roles & skills
Research area: Our interdisciplinary lab uses approaches from both physics and biology to understand how bacteria control their cell shape during growth. Cell shape is physically determined by the cell envelope and notably by the peptidoglycan cell wall. To learn how cells control envelope geometry, architecture, and physical integrity we study cells at the single-cell level using live-cell imaging. We then measure and perturb processes and variables ranging from cell-cycle progression, mechanical forces, and biomass growth, to single-protein movement. Since the cell envelope is also one of the major targets for antibiotic theory, our work ultimately helps to develop better antibacterial strategies.
Student roles: The student will conduct her/his own experiments under the supervision of a senior member of the lab. Depending on the background of the student the project can involve different activities listed below. The precise project will also be chosen depending on research progress prior to the start date, and depending on the preferences of the candidater. However, all students will conduct quantitative live-cell microscopy as a major part of the research project.
For students trained in physics or engineering : - Development of microfluidic chambers and protocols to measure cell growth for multiple generations under the microscope, as well as physically/mechanically perturb their growth and shape.
For students trained in biology : - construction of bacterial mutants through cloning, notably gene deletions, protein overexpression, and the construction of mutants, for proteins implicated in cell-envelope growth. The precise project will be adjusted depending on the interests and skills of the student.
Skills required: This project is open to students from backgrounds in both biology or quantitative sciences such as physics and bioengineering. However, it requires a keen interest in interdisciplinary science at the interface of physics and biology. Independently of background, basic experience in computer coding is desired. For students from biology, prior experience with cloning, molecular biology, or cell biology is helpful but not strictly required. For students from physics, experience with coding is required.
49. UV spectroscopy of periodic tryptophan arrays
Supervisor: Valter Zazubovits
University: Concordia University (Montréal campus)
There are several types of protein assemblies that can be treated as large ordered periodic arrays of pigments, for instance microtubules, actin filaments and tobacco mosaic virus virons. Microtubules form the cytoskeleton of the cells and serve as roads along which the motor proteins walk and deliver their cargo. They are made of multiple copies of the tubulin protein. TMV virons are made of multiple copies of the coat protein. Etc. Thus, these assemblies may be treated as periodic arrays of aminoacids. Of particular interest is tryptophan, the aminoacid featuring the longest-wavelength absorption and emission (280 / 350 nm). Still, this emission is in the UV spectral region.
Thus, microtubiles, actin filaments and tobacco mosaic virons can be used as model systems for photosynthesis research (chlorophyll-protein complexes involved in photosynthesis contain vast networks of interacting chlorophyll molecules, acting as light-harvesting antennae), except they absorb and emit in the UV spectral range. Theoretical / computational works exist that predict that UV excitations can travel along the microtubules for at least several hundred nanometers and that superradiant exciton states may be possible. We would like to verify these predictions experimentally.
From the technical standpoint, the experiments involve prism-TIR fluorescence microscopy, with introducing excitation to the microtubule either directly or via upconverting nanoparticles attached to the microtubules (excited in IR, emitting in UV). Nanoparticles and TMV are available from the collaborators; labeled and unlabeled tubulin is available commercially. Some relatively simple chemistry will be employed to polymerize tubulin and immobilize the microtubules / filaments / virons.
Research area, student roles & skills
Research area: The research of our group is at the intersection between physics, chemistry and biology. We utilize optical methods to study biophysics problems, including protein dynamics, as well as energy and charge transfer processes, for instance those involved in photosynthesis. We also build our own instruments (or modify existing ones), write our own software and engage in computer modeling.
Student roles: The student will become a member of the group that currently contains 2 graduate students and some undergraduate students. The student will participate in instrument design and modifications as well as optical/spectroscopic measurements utilizing existing setup, analyze obtained data, discuss his/her results with the graduate students and supervisor and produce reports and figures. The student will also be expected to familiarize him/herself with relevant literature (directed by the supervisor) and to acquire basic understanding of explored phenomena and of experimental methods. The MITACS Student will gain experiences with experimental techniques (optical spectroscopy and microscopy, some chemistry), equipment and data analysis / software that will be useful for him/her in many areas of science. S/he may become a co-author of a publication.
Skills required: The student should have some knowledge of optics and chemistrey and desire to learn new things. Interest in and predisposition for experimental work is a must. Not being averse to some simple chemistry is a plus. Previous experience with experimental research projects is a plus.
50. Uncovering regulatory DNA elements in wheat under abiotic stress
Wheat is one of the most important cereal crops globally, yet the regulatory landscape governing its gene expression — especially under abiotic stress — remains poorly characterized. This project investigates cis-regulatory elements (CREs) and transcriptome responses in wheat using two complementary technologies: MOA-seq and RNA-seq.
MOA-seq uses micrococcal nuclease (MNase) as a structural probe to map, at high resolution (<30 bp), the footprints of transcription factors (TFs) bound to accessible chromatin regions genome-wide. Unlike ATAC-seq, MOA-seq simultaneously captures nucleosome positioning and TF-occupied cis-elements, providing a richer picture of chromatin architecture and putative regulatory switches. A key focus is the identification of cis-elements derived from transposable elements (TEs) that become conditionally occupied under heat stress.
RNA-seq provides paired gene expression data from the same tissue and stress conditions, enabling direct integration with MOA-seq footprint data: stress-dependent footprints are linked to differentially expressed neighboring genes and to TE transcript activity, building TF-target gene regulatory networks.
The project applies both approaches across two wheat models: Triticum monococcum (diploid, A genome) and Triticum turgidum subsp. durum (tetraploid, AABB genomes), at two developmental stages - vegetative and reproductive - under both control and heat stress conditions. This design allows direct comparison of chromatin accessibility and transcriptome responses across ploidy levels and stress states, and is part of a larger PhD research thesis in the laboratory.
The intern will gain hands-on experience in plant genomics, from wet lab protocols (nuclei isolation, MNase digestion, RNA extraction, library preparation) to introductory computational analyses (read alignment, footprint quality assessment, differential expression).
Research area, student roles & skills
Research area: Our laboratory investigates the regulation of gene expression in wheat using cutting-edge genomic approaches. We focus on understanding how plants respond to abiotic stress - particularly heat and drought - at the chromatin and transcriptome levels. Using MOA-seq (MNase-defined cistrome Occupancy Analysis) and RNA-seq, we map transcription factor binding sites, transposable element-derived cis-regulatory elements, and stress-responsive transcripts across the wheat genome at key developmental stages. Our research bridges fundamental epigenomics with applied breeding goals, aiming to identify regulatory elements underlying stress tolerance in diploid and tetraploid wheat.
Student roles: The Globalink intern will be an active contributor to an ongoing PhD project investigating chromatin regulation and transcriptome responses in wheat under abiotic stress. Working under the direct mentorship of the PhD student Marie Honorine Sène and the principal investigator, the intern will contribute to the wet lab component of the project.
Wet lab responsibilities: -Participate in wheat growth and stress experiments in controlled-environment growth chambers. This implies soil preparation, germination, and plant maintenance in controlled growth chambers. - Help monitor stress phenotypes of the plant with basic measurements like flowering time, height, leaf number, etc. - Assist with plant tissue harvesting at vegetative and reproductive developmental stages - Contribute to nuclei isolation from wheat tissue using Percoll gradient purification - Assist with the nuclease MNase digestion titration experiments for MOA-seq library preparation - Contribute to RNA extraction and quality assessment (NanoDrop, Qubit, Bioanalyzer) for RNA-seq library preparation - Perform gel electrophoresis and TapeStation quality controls on chromatin digestion samples
General responsibilities: - Read and discuss primary scientific literature relevant to the project during weekly lab meetings - Maintain a detailed and organized laboratory notebook - Present progress to the research team at mid- and end-of-internship as an oral presentation - Contribute to a written internship summary report
Skills required: The ideal candidate is a motivated student in biology, biochemistry, genetics, botany, or a related field. Prior laboratory experience in molecular biology is required. The student should have performed at least DNA/RNA extraction, PCR, and gel electrophoresis. Familiarity with plant biology or genomics is a strong asset. Basic exposure to bioinformatics tools (command-line interface, R or Python) is appreciated but not mandatory. Strong organizational skills, attention to detail, and ability to work both independently and collaboratively are essential.
Clubroot is a devastating disease infecting roots of plants of the Brassicaceae family and responsible for 10–15% yield reduction on a global scale. The clubroot pathogen, Plasmodiophora brassicae, is an obligate intracellular biotroph that belongs to the class Phytomyxea. The life cycle of P. brassicae starts in the soil, where resting spores, which can remain viable for up to 20 years, germinate in response to the presence of plant hosts and initiate primary infection. During secondary infection, susceptible plants develop galls that disrupt water and nutrient uptake, leading to wilting, stunting, and, in some instances, death of the infected plant. The mechanisms by which the clubroot pathogen can escape plant immunity in the susceptible host and induce the root galls characteristics of the disease is still unknown. Based on what we know about biotrophic pathogens from other evolutionary groups, effector proteins might play a key role in mediating P. brassicae pathogenicity. Prediction of effectors based on conserved motifs has been very challenging for this pathogen, mainly because of unique features inherent to P. brassicae, including its inability to grow in axenic cultures. This scarcity of information about P. brassicae effectors stresses the need to find other ways to assess more effector candidates to better understand the etiology of the clubroot pathogen. That is precisely one of the projects being developed in our lab, the characterization of P. brassicae effector candidates to study their function during the infection. For that we use biochemistry, molecular biology and microbiology methodologies. We will also generate Arabidopsis plants expressing the effectors in order to investigate if these proteins can affect plant immunity and response to pathogens.
Research area, student roles & skills
Research area: Our Lab is a molecular and applied plant pathology laboratory working on several projects to try to understand biotrophic plant pathogens and insect pests putting at risk the economy in Canada and worldwide. For that we use molecular biology and genomics tools, but we also use classic microbiology and agronomy-based methodologies.
Student roles: The student will play a key role for the project. The student will receive trainings for later perform PCRs, cloning, transformation of E. coli, transformation of A. thaliana, work with proteins. The student will learn a different array of molecular biology methodologies that will help them in their future careers and that will contribute directly to the characterization of P. brassicae effectors. The students will also learn how to work with plants, infect them, and evaluate disease progress. It will have a complete experience.
Skills required: The main skill required from the student is curiosity, critical thinking and love for science. Of course, students with a biochemistry, bioinformatics, molecular biology, microbiology and biotechnology are going to have better chances to enjoy more the projects and to be able to have interesting results that can be published in a peer-review journal. This internship can be the door for a master, a PhD, and an academic career.
52. What drives cell shape? Dissecting vesicle trafficking pathways in Physcomitrium patens
In this project, you'll gain hands-on experience with CRISPR-mediated genome editing and molecular cloning to generate Physcomitrium patens mutant lines expressing GFP-tagged endomembrane markers. Using live-cell confocal microscopy, you'll track the dynamics of organelles such as the ER, Golgi, and vacuole in real time, and assess how disruptions to the endomembrane system alter cell morphology and tip growth. P. patens is an exceptionally well-suited model organism here, with rapid mutant generation and established fluorescent tools that accelerate the work. The project will connect endomembrane trafficking dynamics to the cytoskeletal and molecular mechanisms that underpin cell shape and development, contributing to fundamental questions in plant cell biology.
Research area, student roles & skills
Research area: The plant endomembrane system includes membrane-bound organelles like the ER, Golgi, trans-Golgi network (TGN), and vacuole, as well as smaller vesicles that transport molecular cargo in and out of the cell. I am interested in how these organelles and compartments work together and maintain their identity even though they often share molecular cargo and membranes. This highly dynamic system is required for all kinds of cell and organism-level functions, including how plants adapt and respond to their changing environments.
Student roles: Students will join an inclusive and collaborative lab environment where scientific autonomy is actively encouraged. They will lead their own project — designing and executing experiments, and maintaining a detailed lab notebook documenting aims, protocols, results, and conclusions with close mentorship from the lab supervisor and the support of the research team. Students are expected to engage as genuine team members, contributing their own ideas and hypotheses while benefiting from a constructive, supportive space that nurtures their growth as independent researchers.
Skills required: Students should feel comfortable with standard lab techniques like using a pipette, sterile technique, and preparing chemical solutions. Knowledge of basic genetics and plants would be helpful but is not necessary. Students interested in molecular and cell biology are encouraged to apply.
53. iDNA for vertebrate biodiversity inventories
Supervisor: Yann Surget-Groba
University: Université du Québec en Outaouais (Gatineau campus)
The 15th Conference of the Parties (COP15) to the United Nations Convention on Biological Diversity, held in Montreal in 2022, resulted in the adoption of the Kunming–Montreal Global Biodiversity Framework (GBF). This landmark agreement both acknowledged the threats facing global biodiversity and established a set of goals and targets aimed at halting and reversing biodiversity loss. Achieving these targets depends on the development of biodiversity monitoring tools that can be deployed at large scales. Existing methods often require substantial financial, human, and time investments (e.g., direct observation, trapping, and laboratory analyses). Developing and improving innovative approaches that facilitate the monitoring and management of species and ecosystems is therefore essential to meeting the objectives of the Kunming–Montreal GBF.
This project, conducted in partnership with the Coalition Conservation Mont-Kaaikop, aims to develop such an approach by using invertebrate-derived DNA (iDNA) recovered from the gut contents of invertebrates. By capturing invertebrates (insects and other taxa) and amplifying and sequencing the DNA present in their digestive systems, it is possible to identify their food sources within a given area. Invertebrates can thus serve as valuable biodiversity samplers, providing managers with information on local animal diversity through their feeding habits, behavior, and life cycles, while also reflecting the relative abundance of their prey.
Research area, student roles & skills
Research area: The Ecological and Environmental Genomics lab lead by prof. Yann Surget-Groba is par of the Institute of Temperate Forest Sciences located in the small village of Ripon in the Outaouais region of Quebec, Canada. We use genomic tools to study the evolutionary and conservation biology of various organisms, in particular to study the effect of different forest management systems on biodiversity, and to develop efficient biodiversity inventory methods based on the analysis of environmental DNA. We also investigate the landscape genomics of forest trees to understand their ability to adapt to a rapidly changing environment.
Student roles: The students will first be involved in fieldwork to conduct traditional biodiversity inventories and collect invertebrates for the iDNA analyses. Then, work in the lab will involve DNA extractions and amplicon library preparation for Illumina sequencing. Other side projects are available in the group upon interest (bioinformatics, database development, electronics/transmitter development, environmental DNA analyses...).
Skills required: The student will be required to be confortable conducting fieldwork (if no previous experience doing fieldwork, experience in outdoor activities such as hiking, camping, etc is required). Good physical condition is required to conduct fieldwork in difficult condition (access to the research sites can be difficult requiring hiking on uneven ground carrying equipment). Previous experience in a molecular laboratory (with knowledge of basic methods such as DNA extraction, PCR and gel electrophoresis) is preferable.